Department of Acupuncture, Guang' anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Medicine (Baltimore). 2021 Mar 12;100(10):e25140. doi: 10.1097/MD.0000000000025140.
Human immunodeficiency virus (HIV)-associated distal symmetric peripheral neuropathy (DSPN) is one of the most frequent neurological complications of HIV infection, and causes pain and dysaesthesias in millions globally. Many individuals with this infection report using acupuncture to manage their symptoms, but evidence supporting the use of acupuncture is limited. This systematic review will assess the effectiveness and safety of acupuncture for patients with HIV-associated DSPN.
Databases including MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, Scopus, Web of science, AMED (Allied and Complementary Medicine), the Chinese Biomedical Literature Database, the China National Knowledge Infrastructure, Wanfang Database, VIP Database and clinical trials registers (the WHO International Clinical Trials Registry Platform portal and www.ClinicalTrials.gov) will be electronically searched from inception to December 1, 2020. All randomized controlled trials in English or Chinese without restriction on publication status will be included. Selection of studies, extraction of data, and assessment of studies quality will be independently performed by 2 reviewers. The primary outcome measure will be the change in pain intensity assessed by validated scales. Secondary outcomes include change in neurologic summary scores, quality of life, physical function evaluated by admitted tools, and adverse events related to acupuncture reported in the included trials. If possible, a meta-analysis will be conducted to provide an estimate of the pooled treatment effect using Review Manager 5.3 statistical software. Otherwise, qualitative descriptive analysis will be given. The results will be presented as the risk ratio for binary data and the mean difference (MD) or standardized MD for continuous data.
The results of the systematic review will be disseminated via publication in a peer-reviewed journal and presented at a relevant conference.
This review will be the first review entirely focused on assessing the effectiveness and safety of acupuncture for HIV-associated DSPN.
CRD42020210994.
人类免疫缺陷病毒（HIV）相关的远端对称性周围神经病（DSPN）是 HIV 感染最常见的神经并发症之一，在全球范围内导致数百万人出现疼痛和感觉异常。许多感染这种疾病的人报告说使用针灸来控制他们的症状，但支持针灸使用的证据有限。本系统评价将评估针灸治疗 HIV 相关 DSPN 患者的有效性和安全性。
我们将从建库起到 2020 年 12 月 1 日，对包括 MEDLINE、EMBASE、Cochrane 中央对照试验注册库、Scopus、Web of science、AMED（辅助和补充医学）、中国生物医学文献数据库、中国国家知识基础设施、万方数据库、VIP 数据库和临床试验登记处（世界卫生组织国际临床试验注册平台门户和 www.ClinicalTrials.gov）在内的数据库进行电子检索。我们将纳入所有发表状态不受限制的英语或中文随机对照试验。两名评审员将独立进行研究选择、数据提取和研究质量评估。主要结局指标将是采用经过验证的量表评估的疼痛强度变化。次要结局指标包括神经综合评分、生活质量、采用公认工具评估的身体功能以及纳入试验报告的与针灸相关的不良事件的变化。如果可能，我们将使用 Review Manager 5.3 统计软件进行荟萃分析，以提供汇总治疗效果的估计值。否则，将给予定性描述性分析。结果将以二分类数据的风险比和连续数据的均数差（MD）或标准化 MD 表示。
系统评价的结果将通过在同行评议期刊上发表和在相关会议上展示来传播。
这将是首次完全专注于评估针灸治疗 HIV 相关 DSPN 的有效性和安全性的综述。
PROSPERO 注册号：CRD42020210994。
