Chen Ya-Nan, An Cui-Xia, Wang Ran, Wang Lan, Song Mei, Yu Lu-Lu, Sun Fei-Fei, Wang Xue-Yi
Department of Psychiatry, First Hospital of Hebei Medical University.
Institute of Mental Health, Hebei Medical University, Shijiazhuang, China.
Medicine (Baltimore). 2021 Mar 19;100(11):e24565. doi: 10.1097/MD.0000000000024565.
To determine the effect of earthquake on sleep quality of adults who had experienced Tangshan Earthquake either as infants or fetuses and also investigate whether CRHR1 polymorphism influenced sleep quality in subjects exposed to seismic stress.Totally 556 subjects were enrolled in the current study and were divided into 3 groups, those who had experienced Tangshan Earthquake as infants (group I) or fetuses (group II), and those who had not experienced Tangshan Earthquake (group III). Sleep was evaluated using the Pittsburgh Sleep Quality Index (PQSI). Three single nucleotide polymorphisms of the CRHR1 gene were analyzed.Fifty two (9.4%) subjects had sleep disturbance, including 17 (9.9%) subjects in group I, 24 (13.4%) subjects in group II, and 11 (5.3%) subjects in group III (χ2 = 7.373, P = .025). Moreover, subjects with CRHR1 genotype T/T had a significantly lower rate of sleep disturbance (7.8%) than subjects with genotype C/T and C/C (14.7%; χ2 = 4.845, P = .028). Furthermore, subjects with rs7209436 genotype C had an approximately 2-fold increase in the risk of sleep disturbance versus those who were not genotype C (OR = 1.978, 95% CI (1.045, 3.744).Prenatal and postnatal exposure to seismic stress significantly increases subsequent risk of sleep disturbance in adulthood.
为了确定地震对在婴儿期或胎儿期经历过唐山地震的成年人睡眠质量的影响，并调查促肾上腺皮质激素释放激素受体1（CRHR1）基因多态性是否会影响遭受地震应激的受试者的睡眠质量。本研究共纳入556名受试者，分为3组，即婴儿期经历过唐山地震的受试者（I组）、胎儿期经历过唐山地震的受试者（II组）以及未经历过唐山地震的受试者（III组）。采用匹兹堡睡眠质量指数（PSQI）评估睡眠情况。对CRHR1基因的三个单核苷酸多态性进行了分析。52名（9.4%）受试者存在睡眠障碍，其中I组有17名（9.9%）受试者，II组有24名（13.4%）受试者，III组有11名（5.3%）受试者（χ2 = 7.373，P = 0.025）。此外，CRHR1基因T/T基因型受试者的睡眠障碍发生率（7.8%）显著低于C/T和C/C基因型受试者（14.7%；χ2 = 4.845，P = 0.028）。而且，rs7209436基因C基因型受试者的睡眠障碍风险比非C基因型受试者增加了约2倍（OR = 1.978，95%可信区间（1.045，3.744））。产前和产后暴露于地震应激会显著增加成年后出现睡眠障碍的风险。
