Department of Psychiatry, the First Hospital of Hebei Medical University, Mental Health Institute of the Hebei Medical University, No.89 Donggang Road, Yuhua District, Shijiazhuang, 050031, Hebei, China.
Reprod Biol Endocrinol. 2020 Nov 10;18(1):109. doi: 10.1186/s12958-020-00664-2.
To investigate the long-term effect of prenatal exposure to earthquake stress on diabetes risk in the adulthood.
This study included employees of Tangshan Kailuan Mining Group between July 29, 1976 and April 28, 1977. The exposure group included subjects who experienced the Tangshan Earthquake during their prenatal period and who had lived in Tangshan since birth. The non-exposure group included subjects who were born 1-1.9 years after the earthquake and who had lived in Tangshan since birth. A questionnaire was designed that included sociodemographic information, conditions during pregnancy, and earthquake experience. Anthropometric measurements including height and weight, body mass index (BMI), waist circumference were made. Fasting plasma glucose (FPG) and lipid profiles were also determined.
Totally 947 subjects were included with 397 subjects in the exposed group and 550 subjects in the non-exposed group. The diabetes rate is significant different in these four groups(χ =8.045, P = 0.045). Moreover, 11.8, 7.5 and 8.0% of the subjects who were exposed to earthquake in the 1st, 2nd, and 3rd trimester of pregnancy had diabetes. 5.1% of the subjects had diabetes in non-exposure group. Our multivariate analysis showed that 1st trimester (OR 2.481, 95%CI 1.02, 6.034; P = 0.045) and loss of family members during earthquake (OR 2.452, 95%CI 1.293, 4.653; P = 0.006) were associated with significantly increased risk of diabetes.
Exposure to earthquake during the first trimester of pregnancy and experience of family member loss in the earthquake significantly increased the subsequent risk of diabetes in the middle age (36-39 years of age). Our data suggest that earthquake experience in the early pregnancy has a longer-term effect on diabetes risk during adulthood.
探讨产前地震应激暴露对成年后患糖尿病的长期影响。
本研究纳入了 1976 年 7 月 29 日至 1977 年 4 月 28 日期间的唐山开滦矿业集团员工。暴露组包括在产前经历过唐山地震且出生后一直在唐山生活的受试者。非暴露组包括出生于地震后 1-1.9 年且出生后一直在唐山生活的受试者。设计了一份问卷，其中包括社会人口统计学信息、妊娠期间情况和地震经历。进行了身高、体重、体重指数（BMI）、腰围等人体测量学测量。还测定了空腹血糖（FPG）和血脂谱。
共纳入 947 名受试者，其中暴露组 397 名，非暴露组 550 名。这四组的糖尿病发病率有显著差异（χ²=8.045，P=0.045）。此外，在妊娠 1、2、3 期暴露于地震的受试者中，分别有 11.8%、7.5%和 8.0%患有糖尿病，非暴露组中 5.1%的受试者患有糖尿病。多变量分析显示，妊娠 1 期（OR 2.481，95%CI 1.02，6.034；P=0.045）和地震中失去家庭成员（OR 2.452，95%CI 1.293，4.653；P=0.006）与糖尿病发病风险显著增加相关。
妊娠早期暴露于地震和地震中失去家庭成员会显著增加中年（36-39 岁）后患糖尿病的风险。我们的数据表明，妊娠早期的地震经历对成年后患糖尿病的风险有更长期的影响。
