比较中药治疗儿童或成人白癜风疗效和安全性的系统评价和网络荟萃分析方案。
Comparison of efficacy and safety of traditional Chinese patent medicine in the treatment of vitiligo in children or adults: A protocol for systematic review and network meta-analysis.
机构信息
First College of Clinical Medicine, Shandong University of Traditional Chinese Medicine.
Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China.
出版信息
Medicine (Baltimore). 2021 Mar 19;100(11):e24878. doi: 10.1097/MD.0000000000024878.
BACKGROUND
Vitiligo is a common depigmented skin disease in children or adults, which usually causes considerable psychological burden to life and work for the reason that it affects appearance. The conventional therapies, including external 308 nm excimer laser therapy along with oral administration of western medicine, are associated with distinct disadvantages. Notably, traditional Chinese patent medicine (TCPM) exerts a vital part in treating vitiligo. Currently, no existing research has examined the effectiveness and safety of different TCPMs in treating vitiligo among either child or adult patients. As a result, the present network meta-analysis was carried out for the systematic comparison of the effectiveness of different TCPMs in treating vitiligo.
METHODS
The electronic databases, like PubMed, Web of Science, EMBASE, The Cochrane Library, Chinese Scientific Journals Database, China National Knowledge Infrastructure, Wanfang database and China BioMedical Literature, were searched systemically by 2 reviewers independently from inception to August 2020 to identify relevant randomized controlled trial (RCTs) according to our study inclusion criteria. In data extraction, risk of bias among those enrolled articles was also detected. Besides, the Bayesian network meta-analysis method was utilized to evaluate the evidence and data collected. This adopted the STATA and Win BUGS software for analysis.
RESULTS
The present work assessed the safety and efficacy of different TCPMs in treating vitiligo among child or adult patients.
CONCLUSION
Our findings can shed precious lights on applying TCPMs in clinic and help the clinicians to formulate the efficient diagnostic and therapeutic strategies.
ETHICS AND DISSEMINATION
No ethical approval was needed in this study.
INPLASY REGISTRATION NUMBER
INPLASY2020120050.
背景
白癜风是一种常见的儿童或成人色素减退性皮肤病，由于其影响外观，通常会给生活和工作带来相当大的心理负担。传统疗法，包括外用 308nm 准分子激光治疗和口服西药，都有明显的缺点。值得注意的是，中药（TCPM）在治疗白癜风中起着重要作用。目前，尚无研究评估不同 TCPM 治疗儿童或成人白癜风患者的疗效和安全性。因此，我们进行了这项网络荟萃分析，以系统比较不同 TCPM 治疗白癜风的疗效。
方法
两名审查员独立地从建库开始到 2020 年 8 月，通过电子数据库（如 PubMed、Web of Science、EMBASE、The Cochrane Library、中国科学期刊数据库、中国国家知识基础设施、万方数据库和中国生物医学文献）系统地搜索了相关的随机对照试验（RCT），并根据我们的研究纳入标准进行了筛选。在数据提取过程中，还对纳入的文章进行了偏倚风险评估。此外，采用贝叶斯网络荟萃分析方法对收集到的证据和数据进行评估。该分析采用了 STATA 和 Win BUGS 软件。
结果
本研究评估了不同 TCPM 治疗儿童或成人白癜风患者的安全性和疗效。
结论
我们的研究结果可为临床应用 TCPM 提供参考，并有助于临床医生制定有效的诊断和治疗策略。
伦理和传播
本研究不需要伦理批准。
INPLASY 注册号：INPLASY2020120050。
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