比较补充替代疗法对哮喘儿童的疗效和安全性：系统评价和荟萃分析的方案。
A comparison of efficacy and safety of complementary and alternative therapies for children with asthma: A protocol for systematic review and meta analysis.
机构信息
The First College of Clinical Medicine, Shandong University of Traditional Chinese Medicine.
The Affiliated Hospital of Shandong University of Traditional Chinese Medicine.
出版信息
Medicine (Baltimore). 2021 Mar 19;100(11):e24946. doi: 10.1097/MD.0000000000024946.
BACKGROUND
Bronchial Asthma is a chronic, hyperreactive inflammation of the airway that involves a variety of inflammatory cells. Due to the persistence of airway hyperresponsiveness, lung function is progressively damaged, making asthma more stubborn and difficult to heal. In recent years, the prevalence of childhood asthma is still on an increasing trend. Repeated asthma attacks not only affect children's life and learning, but also bring greater economic and mental burden to children's families, and even threaten children's lives. Traditional treatment methods such as oral western medicine, atomization therapy has obvious limitations, and the complementary and alternative therapy is an effective method to treat asthma in children. This study will evaluate the efficacy and safety of various complementary and alternative therapies for children with asthma by means of mesh meta-analysis. In order to provide the basis for clinical rational use.
METHODS
Use the computer to search the self-built database until January 2021, the China National Knowledge Infrastructure, Wanfang Database, Chinese Scientific Journals Database, China Biomedical Literature Database, PubMed, Cochrance Library, EMBASE, Web of Science, Clinical Trials and other electronic databases to collect RCT studies on complementary and alternative therapies for for children with asthma. We will screen the relevant literature included in the systematic review/meta analysis. At the same time, Revman 5.3 software will be used for meta-analysis, and grade will be used to grade the quality of evidence in the network meta-analysis.
RESULTS
This study will compare the efficacy and safety of different complementary and alternative therapies to treat childhood asthma, and evaluate and rank different interventions.
CONCLUSION
The combined use of complementary and alternative therapies for childhood asthma on the basis of conventional basic treatment can improve clinical efficacy, reduce the occurrence of adverse reactions, improve the quality of life of children, and provide strong support for the rational use of clinicians.
INPLASY REGISTRATION NUMBER
INPLASY202120005.
背景
支气管哮喘是一种气道的慢性、高反应性炎症，涉及多种炎症细胞。由于气道高反应性的持续存在，肺功能逐渐受损，使哮喘更加顽固和难以治愈。近年来，儿童哮喘的患病率仍呈上升趋势。哮喘反复发作不仅影响儿童的生活和学习，也给儿童家庭带来更大的经济和精神负担，甚至威胁儿童的生命。传统的治疗方法如口服西药、雾化治疗等有明显的局限性，而补充和替代疗法是治疗儿童哮喘的有效方法。本研究将通过网状荟萃分析评价各种补充和替代疗法治疗儿童哮喘的疗效和安全性，为临床合理应用提供依据。
方法
采用计算机检索自建数据库至 2021 年 1 月，中国知网、万方数据库、中文科技期刊数据库、中国生物医学文献数据库、PubMed、Cochrance 图书馆、EMBASE、Web of Science、ClinicalTrials 等电子数据库，收集补充和替代疗法治疗儿童哮喘的 RCT 研究。同时，对纳入的系统评价/荟萃分析相关文献进行筛选，采用 Revman5.3 软件进行网状荟萃分析，并对网络荟萃分析中的证据质量进行分级。
结果
本研究将比较不同补充和替代疗法治疗儿童哮喘的疗效和安全性，并对不同干预措施进行评价和排序。
结论
在常规基础治疗的基础上联合使用补充和替代疗法治疗儿童哮喘，可以提高临床疗效，减少不良反应的发生，提高儿童的生活质量，为临床医生的合理用药提供有力支持。
INPLASY 注册号：INPLASY202120005.
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