Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kami-chou, Itabashi-ku, Tokyo, Japan.
Section on Genetics and Epidemiology, Research Division, Joslin Diabetes Center.
Medicine (Baltimore). 2021 Mar 19;100(11):e25049. doi: 10.1097/MD.0000000000025049.
A recent report demonstrated that the prevalence of obstructive sleep apnea (OSA) is 67.6% among Caucasian and Chinese patients with primary aldosteronism (PA). Moreover, the report showed a significant association between plasma aldosterone concentration (PAC) and the severity of OSA in Caucasian patients. However, no studies have examined the prevalence of OSA with PA or the association of its severity with PAC in the Japanese population. We retrospectively evaluated the prevalence and severity of OSA in 71 newly diagnosed Japanese patients with PA. Thirty-nine (55%) of the 71 patients were diagnosed with OSA, and 69% of PA patients with OSA reported snoring. No correlation was found between the respiratory event index (REI), snoring index, and PAC and plasma renin activity (PRA). In contrast, REI correlated significantly with body mass index (BMI), which was significantly correlated with PRA. In conclusion, although the severity of OSA did not correlate with PAC and PRA, there was a high prevalence of OSA among Japanese patients with PA. Moreover, the severity of OSA was strongly affected by BMI. Thus, the examination of OSA in patients with PA and the proper management of OSA might be important for the Japanese population.
最近的一份报告表明，原发性醛固酮增多症（PA）患者中，白种人和中国人的阻塞性睡眠呼吸暂停（OSA）患病率为 67.6%。此外，该报告显示，白种人患者的血浆醛固酮浓度（PAC）与 OSA 的严重程度之间存在显著关联。然而，尚无研究检查过日本人群中 PA 与 OSA 的患病率或其严重程度与 PAC 的关联。我们回顾性评估了 71 例新诊断的日本 PA 患者的 OSA 患病率和严重程度。71 例患者中，39 例（55%）被诊断为 OSA，有 OSA 的 PA 患者中 69%有打鼾症状。呼吸事件指数（REI）、打鼾指数与 PAC 和血浆肾素活性（PRA）之间无相关性。相比之下，REI 与体重指数（BMI）显著相关，BMI 与 PRA 显著相关。总之，尽管 OSA 的严重程度与 PAC 和 PRA 无相关性，但日本 PA 患者中 OSA 的患病率很高。此外，OSA 的严重程度受 BMI 影响较大。因此，对于日本人群，检查 PA 患者的 OSA 并对其进行适当的 OSA 管理可能非常重要。
