Zhou Juan, Zhao Jing, Su Chunxia
Department of Medical Oncology, Shanghai Pulmonary Hospital & Thoracic Cancer Institute, Tongji University School of Medicine, Shanghai, China.
Curr Cancer Drug Targets. 2021;21(8):631-639. doi: 10.2174/1568009619666210316112333.
Cancer stem cells (CSCs) represent a small population of cancer cells that are able to self-renew and initiate tumors, which undergo epigenetic, epithelial-mesenchymal, immunological, and metabolic reprogramming to adapt to the tumor microenvironment as well as survive host defense or therapeutic insults. The metabolic reprogramming that accompanies cancer onset is known to be critical for the disease pathogenesis. A coordinated dysregulation of lipid metabolism is observed in nearly all cancer types. In addition to fulfilling the basic requirements of structural lipids for membrane synthesis, lipids function importantly as signaling molecules and contribute to energy homeostasis. In this review, we summarize the current progress in the attractive research field of aberrant lipid metabolism regarding CSCs in cancer progression, which provides insights into therapeutic agents targeting CSCs based upon their modulation of lipid metabolism.
癌症干细胞（CSCs）是一小群能够自我更新并引发肿瘤的癌细胞，它们经历表观遗传、上皮-间质转化、免疫和代谢重编程，以适应肿瘤微环境，并在宿主防御或治疗攻击中存活下来。已知伴随癌症发生的代谢重编程对疾病发病机制至关重要。几乎在所有癌症类型中都观察到脂质代谢的协同失调。除了满足膜合成所需结构脂质的基本需求外，脂质还作为信号分子发挥重要作用，并有助于能量稳态。在本综述中，我们总结了关于癌症进展中CSCs异常脂质代谢这一引人关注的研究领域的当前进展，这为基于脂质代谢调节的CSCs靶向治疗药物提供了见解。
