Department of Anesthesiology, Amir Alam Hospital Complexes, Sa'adi Street, Tehran University of Medical Sciences, Tehran,Iran.
Department of Internal Medicine, Amir Alam Hospital Complexes, Sa'adi Street, Tehran University of Medical Sciences, Tehran,Iran.
Endocr Metab Immune Disord Drug Targets. 2021;21(12):2191-2202. doi: 10.2174/1871530321666210316103403.
In Covid-19 infection, leukopenia, inflammation, and elevated liver enzymes are found in most patients. Also, vitamin D deficiency attenuates the immune system and predisposes a person to being more susceptible to infection. In this context, we aimed to evaluate vitamin D, electrolytes, complete blood count, liver enzymes, urea, creatinine, albumin, CRP and ESR levels in patients with Covid-19.
We conducted a cross-sectional study on 118 patients with Covid-19 who were hospitalized from 2020/2/19 to 2020/4/3 in ICU. Serum levels of electrolytes, liver enzymes, blood factors, urea, creatinine, CRP and ESR, as well as anthropometric parameters and serum vitamin D concentration, were measured.
A total of 118 patients (80 male and 38 female) were enrolled in the study (65.05±15.75 years). Only 5.08% of patients had no risk factors and 55.9% had ≥ 2 risk factors. Diabetes (44.1%) and obesity (23.7%) were more common among patients. Laboratory findings showed that 80.50% of patients had hyponatremia, but other electrolytes including K, Mg, Ca and P were normal in the majority of participants as well as CBC, Cr, Urea, Alb, ALT and ALKP. The AST concentration increased in most patients (66.94%). All patients had high levels of inflammatory factors such as CRP and ESR. The mean of 25-hydroxy-vitamin D levels in participants (25.95 ± 14.56 ng/mL) was lower than its levels in the general population. However, it was not statistically significant (P= 0.88). A significant negative correlation was found between vitamin D and ALT (P= 0.02, -0.21) as well as vitamin D and CRP (P= 0.05, -0.17).
Due to the regulatory role of vitamin D in the immune system and low levels of vitamin D in Covid-19 infected patients, the evaluation of vitamin D levels and prescribed supplements, if necessary, is suggested.
在新冠病毒感染中，大多数患者的白细胞减少、炎症和肝酶升高。此外，维生素 D 缺乏会削弱免疫系统，使人更容易感染。在这种情况下，我们旨在评估新冠病毒感染患者的维生素 D、电解质、全血细胞计数、肝酶、尿素、肌酐、白蛋白、CRP 和 ESR 水平。
我们对 2020 年 2 月 19 日至 2020 年 4 月 3 日在 ICU 住院的 118 例新冠病毒感染患者进行了一项横断面研究。测量了电解质、肝酶、血液因素、尿素、肌酐、CRP 和 ESR 以及人体测量参数和血清维生素 D 浓度。
共纳入 118 例患者（80 例男性和 38 例女性）（65.05±15.75 岁）。仅有 5.08%的患者无危险因素，55.9%的患者有≥2 个危险因素。糖尿病（44.1%）和肥胖（23.7%）在患者中更为常见。实验室结果显示，80.50%的患者存在低钠血症，但大多数患者的其他电解质（包括 K、Mg、Ca 和 P）以及全血细胞计数、Cr、Urea、Alb、ALT 和 ALKP 均正常。大多数患者的 AST 浓度升高（66.94%）。所有患者的 CRP 和 ESR 等炎症因子水平均较高。参与者 25-羟维生素 D 水平的平均值（25.95 ± 14.56ng/mL）低于一般人群，但无统计学意义（P=0.88）。维生素 D 与 ALT（P=0.02，-0.21）和维生素 D 与 CRP（P=0.05，-0.17）呈显著负相关。
由于维生素 D 在免疫系统中的调节作用以及新冠病毒感染患者中维生素 D 水平较低，建议评估维生素 D 水平并在必要时补充。
