Kong Qingduo, Wei Hongyi, Zhang Jing, Li Yilin, Wang Yongjun
Department of Obstetrics and Gynecology, Peking University International Hospital, Life Park of Zhongguancun, Changping District, Beijing, 102206, China.
Clinical Medical College, Weifang Medical University, Weicheng District, Weifang, 261000, Shandong, China.
J Ovarian Res. 2021 Mar 16;14(1):45. doi: 10.1186/s13048-021-00793-1.
Laparoscopy has been widely used for patients with early-stage epithelial ovarian cancer (eEOC). However, there is limited evidence regarding whether survival outcomes of laparoscopy are equivalent to those of laparotomy among patients with eEOC. The result of survival outcomes of laparoscopy is still controversial. The aim of this meta-analysis is to analyze the survival outcomes of laparoscopy versus laparotomy in the treatment of eEOC.
According to the keywords, Pubmed, Embase, Cochrane Library and Clinicaltrials.gov were searched for studies from January 1994 to January 2021. Studies comparing the efficacy and safety of laparoscopy versus laparotomy for patients with eEOC were assessed for eligibility. Only studies including outcomes of overall survival (OS) were enrolled. The meta-analysis was performed using Stata software (Version 12.0) and Review Manager (Version 5.2).
A total of 6 retrospective non-random studies were included in this meta-analysis. The pooled results indicated that there was no difference between two approaches for patients with eEOC in OS (HR = 0.6, P = 0.446), progression-free survival (PFS) (HR = 0.6, P = 0.137) and upstaging rate (OR = 1.18, P = 0.54). But the recurrence rate of laparoscopic surgery was lower than that of laparotomic surgery (OR = 0.48, P = 0.008).
Laparoscopy and laparotomy appear to provide comparable overall survival and progression-free survival outcomes for patients with eEOC. Further high-quality studies are needed to enhance this statement.
腹腔镜检查已广泛应用于早期上皮性卵巢癌（eEOC）患者。然而，关于腹腔镜检查的生存结果在eEOC患者中是否等同于开腹手术，证据有限。腹腔镜检查的生存结果仍存在争议。本荟萃分析的目的是分析腹腔镜检查与开腹手术治疗eEOC的生存结果。
根据关键词，检索了1994年1月至2021年1月期间PubMed、Embase、Cochrane图书馆和Clinicaltrials.gov上的研究。评估比较腹腔镜检查与开腹手术治疗eEOC患者的疗效和安全性的研究是否符合纳入标准。仅纳入包括总生存期（OS）结果的研究。使用Stata软件（版本12.0）和Review Manager（版本5.2）进行荟萃分析。
本荟萃分析共纳入6项回顾性非随机研究。汇总结果表明，对于eEOC患者，两种手术方式在OS（HR = 0.6，P = 0.446）、无进展生存期（PFS）（HR = 0.6，P = 0.137）和分期上升率（OR = 1.18，P = 0.54）方面无差异。但腹腔镜手术的复发率低于开腹手术（OR = 0.48，P = 0.008）。
对于eEOC患者，腹腔镜检查和开腹手术似乎能提供相当的总生存期和无进展生存期结果。需要进一步的高质量研究来强化这一结论。
