Salat-Baroux J, Antoine J M, Giacomini P, Alvarez S, Tibi C, Cornet D, Mandelbaum J, Plachot M, Firmin C, Kelly R
Department of Obstetrics and Gynaecology, Tenon Hospital, University, Paris VI, France.
Hum Reprod. 1988 Apr;3(3):281-4. doi: 10.1093/oxfordjournals.humrep.a136696.
The prognostic value of a decrease in oestradiol-17 beta (E2) on the day after HCG injection in stimulated cycles has been related to a premature increase in plasma progesterone (P) on the day before HCG injection. This retrospective study was carried out on 363 patients who were divided into four groups. Patients in group A were given clomiphene citrate plus human menopausal gonadotrophin (HMG) to stimulate follicle growth, and they were subdivided into subgroups A1 and A2 who showed an increase or a decrease in E2 levels after HCG injection. The changes in E2 were greater than 10% of the levels on the previous day. Patients in group B were stimulated by HMG and were similarly subdivided into subgroups B1 and B2 according to their E2 levels. The number of oocytes recovered and the incidence of pregnancy was significantly higher in A2 as compared with A1, and higher but not significantly so in B2 versus B1. Moreover, in subgroups A1 and B1 the day before the decrease of E2 was marked by a significant rise in LH before the HCG injection. We suggest that oocyte recovery is deferred in these cases.
在促排卵周期中，注射人绒毛膜促性腺激素（HCG）后第1天雌二醇-17β（E2）水平下降的预后价值与HCG注射前1天血浆孕酮（P）过早升高有关。本回顾性研究对363例患者进行，将其分为四组。A组患者给予枸橼酸氯米芬加人绝经期促性腺激素（HMG）以刺激卵泡生长，再根据HCG注射后E2水平升高或降低将其细分为A1和A2亚组。E2的变化幅度大于前1天水平的10%。B组患者用HMG刺激，并根据E2水平同样细分为B1和B2亚组。与A1亚组相比，A2亚组回收的卵母细胞数量和妊娠发生率显著更高，B2亚组与B1亚组相比虽更高但无显著差异。此外，在A1和B1亚组中，E2下降前1天的特征是HCG注射前LH显著升高。我们认为在这些病例中卵母细胞回收延迟。
