Department of Pediatrics, Acibadem University Faculty of Medicine, Turkey.
Department of Neurology, Acibadem University Faculty of Medicine, Turkey.
Brain Dev. 2021 Jun;43(6):729-733. doi: 10.1016/j.braindev.2021.02.003. Epub 2021 Mar 13.
Guillain-Barré syndrome (GBS) is the most prevalent cause of acquired paralytic neuropathy in children, however, ataxia as the initial presenting sign in children is very rare. Antiganglioside antibodies are presumed to have an important role in the pathophysiology and some phenotypic correlations have been reported. Anti-GM2 antibody, unlike other antibodies, is far less detected in GBS. Here, we report a 7.5-year-old female, initially presenting with ataxia, an atypical presenting symptom in a child, is promptly diagnosed and treated successfully as GBS. Atypical history of urinary infection in our patient is an interesting aspect. The presence of isolated anti-GM2 IgM antibody and ataxia in a pediatric patient is rare. In this case report, we aim to describe an atypical initial presentation, with positive anti-GM2 antibodies, as well as review literature on isolated anti-GM2 positive pediatric GBS patients.
格林-巴利综合征（GBS）是儿童获得性麻痹性神经病最常见的原因，然而，共济失调作为儿童的初始表现非常罕见。抗神经节苷脂抗体被认为在病理生理学中起重要作用，并且已经报道了一些表型相关性。与其他抗体不同，抗 GM2 抗体在 GBS 中检测到的频率要低得多。在这里，我们报告了一例 7.5 岁女性，最初表现为共济失调，这是儿童中一种非典型的表现症状，迅速被诊断并成功治疗为 GBS。我们患者的尿路感染不典型病史是一个有趣的方面。在儿科患者中，孤立性抗 GM2 IgM 抗体和共济失调的存在非常罕见。在本病例报告中，我们旨在描述一种非典型的初始表现，以及伴有阳性抗 GM2 抗体，并复习有关孤立性抗 GM2 阳性儿科 GBS 患者的文献。
