Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Precision Medicine Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Trends Cell Biol. 2021 Jun;31(6):424-427. doi: 10.1016/j.tcb.2021.03.003. Epub 2021 Mar 13.
Reversal of atherosclerosis has been well documented in humans on intensive lifestyle changes or lipid-lowering therapies. The development of mouse models has greatly advanced our understanding of molecular mechanisms underlying this biological process. I seek to summarize the established mouse models and highlight the recent therapeutic progress on plaque regression.
在人类中，通过强化生活方式改变或降脂治疗，动脉粥样硬化的逆转已得到充分证实。小鼠模型的发展极大地促进了我们对这一生物学过程背后的分子机制的理解。我试图总结已建立的小鼠模型，并重点介绍斑块消退的最新治疗进展。
