Graduate student of Graduate Program in Veterinary Science (PPGCVET), Universidade Federal de Uberlândia (UFU), Uberlândia, Minas Gerais, Brazil.
Graduate student of Graduate Program in Veterinary Science (PPGCVET), Universidade Federal de Uberlândia (UFU), Uberlândia, Minas Gerais, Brazil.
Ann Endocrinol (Paris). 2021 Apr;82(2):107-111. doi: 10.1016/j.ando.2021.03.002. Epub 2021 Mar 13.
Acromegaly is an endocrine disease that leads to elevated production and secretion of growth hormone (GH). It can occur in adult and aged cats and is usually associated with neoplasms, such as functional pituitary macroadenoma of somatotropic cells. In dogs it is usually related to an increase in serum progesterone that induces production of GH by the mammary glands. The main clinical signs are related to insulin resistance and the anabolic effect induced by GH: polyuria, polydipsia, polyphagia, increased tissue growth, weight gain, prognathism, and other changes. The condition can be diagnosed from clinical signals and imaging associated to measurement of serum concentrations of GH and insulin-like growth factor 1 (IGF-1, also known as somatomedin C). The main therapeutic modalities are radiotherapy, hypophysectomy, and several drugs such as somatostatin analogs, dopaminergic agonists and GH receptor antagonists. The present review aims to provide a relevant animal model of acromegaly with an update on the therapeutic approach that may help clinicians to consider the GH axis-IGF-1 system, its pathogenesis and the clinical signs induced by this hormonal disorder.
肢端肥大症是一种内分泌疾病，导致生长激素（GH）的产生和分泌增加。它可以发生在成年和老年猫中，通常与肿瘤有关，如生长激素细胞的功能性垂体大腺瘤。在狗中，它通常与血清孕激素的增加有关，孕激素会诱导乳腺产生 GH。主要的临床症状与 GH 诱导的胰岛素抵抗和合成代谢作用有关：多尿、多饮、多食、组织生长增加、体重增加、突嘴和其他变化。可以通过临床信号和与测量血清 GH 和胰岛素样生长因子 1（IGF-1，也称为生长介素 C）浓度相关的影像学来诊断该疾病。主要的治疗方法是放射治疗、垂体切除术和几种药物，如生长抑素类似物、多巴胺激动剂和 GH 受体拮抗剂。本综述旨在提供肢端肥大症的相关动物模型，并更新治疗方法，这可能有助于临床医生考虑 GH 轴-IGF-1 系统、其发病机制以及由这种激素紊乱引起的临床症状。
