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用于宠物即时检测的化学传感器和生物传感器：伴侣动物个性化诊断的机遇

Chemical Sensors and Biosensors for Point-of-Care Testing of Pets: Opportunities for Individualized Diagnostics of Companion Animals.

作者信息

Fonseca Wilson Tiago, Parra Vello Tatiana, Lelis Gabrielle Coelho, Ferreira Deleigo Ana Vitória, Takahira Regina Kiomi, Martinez Diego Stéfani Teodoro, de Oliveira Rafael Furlan

机构信息

Brazilian Nanotechnology National Laboratory (LNNano), Brazilian Center for Research in Energy and Materials (CNPEM), 13083-100 Campinas, Brazil.

Mackenzie Institute for Research in Graphene and Nanotechnologies (MackGraphe), Mackenzie Presbyterian Institute (IPM), 01302-907 São Paulo, Brazil.

出版信息

ACS Sens. 2025 May 23;10(5):3222-3238. doi: 10.1021/acssensors.4c03664. Epub 2025 Apr 22.

DOI:10.1021/acssensors.4c03664
PMID:40259889
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12105083/
Abstract

Point-of-care testing (POCT) is recognized as one of the most disruptive medical technologies for rapid and decentralized diagnostics. Successful commercial examples include portable glucose meters, pregnancy tests, and COVID-19 self-tests. However, compared to advancements in human healthcare, POCT technologies for companion animals (pets) remain significantly underdeveloped. This Review explores the latest advancements in pet POCT and examines the challenges and opportunities in the field for individualized diagnostics of cats and dogs. The most frequent diseases and their respective biomarkers in blood, urine, and saliva are discussed. We examine key strategies for developing the next-generation POCT devices by harnessing the potential of selective (bio)receptors and high-performing transducers such as lateral flow tests and electrochemical (bio)sensors. We also present the most recent research initiatives and the successful commercial pet POCT technologies. We discuss future trends in the field, such the role of biomarker discovery and development of wearable, implantable, and breath sensors. We believe that advancing pet POCT technologies benefits not only animals but also humans and the environment, supporting the One Health approach.

摘要

即时检验（POCT）被认为是用于快速和分散诊断的最具颠覆性的医疗技术之一。成功的商业范例包括便携式血糖仪、妊娠测试和新冠病毒自我检测。然而，与人类医疗保健的进展相比，用于伴侣动物（宠物）的POCT技术仍显著欠发达。本综述探讨了宠物POCT的最新进展，并审视了该领域在猫和狗个体化诊断方面的挑战与机遇。讨论了血液、尿液和唾液中最常见的疾病及其各自的生物标志物。我们研究了通过利用选择性（生物）受体和高性能换能器（如侧向流动测试和电化学（生物）传感器）的潜力来开发下一代POCT设备的关键策略。我们还介绍了最新的研究计划以及成功的商业宠物POCT技术。我们讨论了该领域的未来趋势，如生物标志物发现的作用以及可穿戴、可植入和呼吸传感器的开发。我们相信，推进宠物POCT技术不仅有益于动物，也有益于人类和环境，支持“同一健康”理念。

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