Reproductive Center, The Third Affiliated Hospital of Zhengzhou University, 7 Rehabilitation Street, Erqi District, Zhengzhou, 450000, China.
Reproductive Center, The Third Affiliated Hospital of Zhengzhou University, 7 Rehabilitation Street, Erqi District, Zhengzhou, 450000, China.
J Gynecol Obstet Hum Reprod. 2021 Sep;50(7):102111. doi: 10.1016/j.jogoh.2021.102111. Epub 2021 Mar 13.
To explore the pregnancy outcomes, and neonatal status, arising from embryo transfer in unicornual uterine infertility patients.
We analyzed 2499 cycles of clinical data from in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) from 1st May 2016 to 1st May 2018 in the Reproductive Center of the Third Affiliated Hospital of Zhengzhou University, including 109 women with unicornuate uterus (the observation group) and 2390 women with normally shaped uterus (the control group).
There were no significant differences in embryo implantation rate, clinical pregnancy rate or miscarriage rate (41.88 % VS 42.36 %, P = 0.904; 48.62 % VS 55.94 %, P = 0.133; 11.01 % VS 8.99 %, P = 0.474) between the two groups. The live birth rate in the observation group was lower than that in the control group (35.78 % VS 45.82 %, P = 0.040). The fetal birth weight of the observation group was lower than that of the control group among single-born live births (3009.12 ± 430.59 g VS 3413.40 ± 492.25 g, P = 0.017), but the differences were not observed in the sex ratio at birth, premature birth rate, low birth weight infant (LBW) rate and macrosomia rate (P > 0.05). The fetal birth weight of the observation group was lower than that of the control group among twins live births (2480.00 ± 190.32 g VS 2606.02 ± 471.59 g), but the difference between the groups did not reach statistical significance (P > 0.05)．Logistic regression analysis showed that age, number of embryos transplanted and uterine morphology were independent influencing factors of live birth.
Compared with women with normal uterus, the live birth rate of women with unicornuate uterus is low, and the birth weight of newborns with single birth is reduced.
探讨 unicornuate 子宫不孕患者胚胎移植的妊娠结局和新生儿状况。
我们分析了 2016 年 5 月 1 日至 2018 年 5 月 1 日郑州大学第三附属医院生殖中心 2499 个体外受精/胞浆内单精子注射-胚胎移植（IVF/ICSI-ET）周期的临床资料，其中 unicornuate 子宫患者 109 例（观察组），正常子宫患者 2390 例（对照组）。
两组胚胎着床率、临床妊娠率和流产率差异均无统计学意义（41.88% VS 42.36%，P=0.904；48.62% VS 55.94%，P=0.133；11.01% VS 8.99%，P=0.474）。观察组活产率低于对照组（35.78% VS 45.82%，P=0.040）。单胎活产中，观察组胎儿出生体重低于对照组（3009.12±430.59 g VS 3413.40±492.25 g，P=0.017），但两组间出生性别比、早产率、低出生体重儿（LBW）率和巨大儿率差异无统计学意义（P＞0.05）。双胎活产中，观察组胎儿出生体重低于对照组（2480.00±190.32 g VS 2606.02±471.59 g），但差异无统计学意义（P＞0.05）。Logistic 回归分析显示，年龄、移植胚胎数和子宫形态是活产的独立影响因素。
与正常子宫妇女相比， unicornuate 子宫妇女的活产率较低，单胎新生儿的出生体重降低。
