Laboratory of Experimental Endocrinology, Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
J Physiol Pharmacol. 2020 Dec;71(6). doi: 10.26402/jpp.2020.6.04. Epub 2021 Mar 13.
Physical activity is crucial for maintaining health. Here we investigated the preconditioning effects of exercise on the vulnerability of gastric mucosa to ulcerogenic action of indomethacin (IM, 35 mg/kg, s.c.) or cold-restraint stressor (CR, 3 h, 10°C) in male rats. Single or repeated (5 days) training was used either voluntarily (2 h/day, wheel running) or in a forced way (treadmill). The intensity of the later was either "moderate" (9 m/min, 15 min) or "intensive" (15 m/min, 30 min). All protocols were confirmed by elevated plasma corticosterone and increased tail flick latencies (analgesia). IM-induced ulceration was attenuated by single intensive forced exercise, repeated voluntary and moderate forced exercise. On the contrary, single 2 h voluntary session aggravated the IM-induced ulceration. The ulcerogenic effect of CR was aggravated by single and repeated voluntary and single intensive forced exercise, while repeated moderate forced running was gastroprotective. Single moderate forced running did not influence the ulcerogenic effect of both agents. The results suggest that physical training might have both beneficial and harmful effects on the vulnerability of gastric mucosa to ulcerogenic stimuli depending on the nature of ulcerogenic stimulus as well as the intensity of running and its duration.
体育活动对保持健康至关重要。在这里，我们研究了运动对吲哚美辛（IM，35mg/kg，sc）或冷束缚应激源（CR，3h，10°C）致胃黏膜易损性的预处理作用，以雄性大鼠为研究对象。单次或重复（5 天）训练采用自愿（每天 2 小时，转轮跑步）或强制方式（跑步机）。后一种方式的强度为“中等”（9m/min，15min）或“剧烈”（15m/min，30min）。所有方案均通过提高血浆皮质酮和增加尾巴拍打潜伏期（镇痛）得到确认。单次剧烈强制运动、重复自愿和中等强度强制运动均可减轻 IM 诱导的溃疡。相反，单次 2 小时自愿运动加重了 IM 诱导的溃疡。单次和重复自愿以及单次剧烈强制运动加重了 CR 诱导的溃疡，而重复中等强度强制跑步则具有胃保护作用。单次中等强度强制跑步对两种药物的致溃疡作用没有影响。研究结果表明，体育训练可能对胃黏膜对致溃疡刺激的易损性产生有益和有害的影响，这取决于致溃疡刺激的性质以及跑步的强度和持续时间。
