Cornea & Anterior Segment Service, L V Prasad Eye Institute, Bhubaneswar, Odisha, India.
Cornea and Anterior Segment Service, L V Prasad Eye Institute, Vijayawada, Andhra Pradesh, India.
Indian J Ophthalmol. 2021 Apr;69(4):806-811. doi: 10.4103/ijo.IJO_1624_20.
Thygeson's superficial punctate keratitis (TSPK) is a chronic disorder with episodes of exacerbations and remissions which span over years to decades. Typical features of the disease include multiple, grayish white, intraepithelial corneal lesions with minimal or no conjunctival involvement. The exact etiopathogenesis of this entity is unknown. However, it may have a genetic association with HLA-DR3, an antigen proved to be associated with immunogenic responses. Treatment of the disease consists of artificial tears, topical corticosteroids, topical cyclosporine, topical tacrolimus, or usage of soft contact lenses. TSPK should be considered as a diagnosis of exclusion in cases of bilateral superficial punctate keratopathy of long duration. Thirteen patients of TSPK were examined during the last 6 years (2014-2019) at our Institute. Visual acuity was 20/20 to 20/30 in majority cases. All patients required lubricants.
泰格森浅层点状角膜炎（TSPK）是一种慢性疾病，其病情恶化和缓解反复发作，持续数年至数十年。该病的典型特征包括多个灰白色、上皮内角膜病变，伴或不伴轻微的结膜受累。该疾病的确切病因尚不清楚。然而，它可能与 HLA-DR3 存在遗传关联，这种抗原已被证明与免疫反应有关。该病的治疗包括人工泪液、局部皮质类固醇、局部环孢素、局部他克莫司或软性隐形眼镜的使用。对于双侧浅层点状角膜病变且病程较长的患者，应考虑排除 TSPK 作为诊断。在过去的 6 年（2014-2019 年）中，我们研究所检查了 13 例 TSPK 患者。大多数患者的视力为 20/20 至 20/30。所有患者均需要使用润滑剂。
