Kinnman E, Aldskogius H
Department of Anatomy, Karolinska Institutet, Stockholm, Sweden.
J Comp Neurol. 1988 Apr 22;270(4):569-74. doi: 10.1002/cne.902700410.
Peripheral transganglionic transport of horseradish peroxidase (HRP) was used to label afferent fibers in the taste buds and lingual epithelium 2-12 weeks after chronic chorda tympani or combined chorda tympani-lingual nerve lesions. From 4-12 weeks after a chronic chorda tympani lesion, taste buds could be found. These were innervated by fibers from the ipsilateral lingual nerve. From 8-12 weeks after a chronic chorda tympani-lingual nerve lesion, nerve fibers from the contralateral lingual nerve could be found in a few taste buds on the denervated side of the tongue. Thus, collateral sprouting took place over the midline in this instance. These findings indicate that intact gustatory axons do not sprout into denervated taste buds, but trigeminal fibers in the lingual nerve do have this ability.
在慢性鼓索神经或鼓索神经-舌神经联合损伤后2至12周，利用辣根过氧化物酶（HRP）的外周跨神经节运输来标记味蕾和舌上皮中的传入纤维。在慢性鼓索神经损伤后4至12周，可以发现味蕾。这些味蕾由同侧舌神经的纤维支配。在慢性鼓索神经-舌神经联合损伤后8至12周，在舌失神经支配侧的少数味蕾中可发现来自对侧舌神经的神经纤维。因此，在这种情况下中线处发生了侧支发芽。这些发现表明，完整的味觉轴突不会向失神经支配的味蕾发芽，但舌神经中的三叉神经纤维确实具有这种能力。
