Hayden D W, Johnson K H, Wolf C B, Westermark P
Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, St. Paul 55108.
J Comp Pathol. 1988 Feb;98(2):195-204. doi: 10.1016/0021-9975(88)90018-7.
Systemic amyloidosis involving the digestive tract is described in an 11-year-old Morgan stallion. The disease was characterized clinically by weight loss, ptyalism, anaemia, persistent mature neutrophilia, hypoalbuminaemia and hypergammaglobulinaemia. The D-xylose absorption test indicated malabsorption. Necropsy revealed oral, oesophageal and gastric ulcers and reddened segments of small bowel mucosa with scant haemorrhages. Microscopically, amyloid deposits were found throughout all tissue layers of the digestive tract, except the serosa. Deposits of amyloid were most apparent in the small bowel mucosa and submucosal arteries. Amyloid was also present in the spleen and lymph nodes and to a lesser extent in the liver, kidneys, lungs, pancreas and bone marrow. All amyloid deposits gave the typical histochemical reaction for AA amyloid with the KMnO4-Congo red stain procedure and immunohistochemical cross-reactivity was demonstrated with antisera to both canine and bovine protein AA by the peroxidase-antiperoxidase technique. The cause of the amyloidosis was not identified, although the haematological and serological data were compatible with an underlying chronic inflammatory process.
一头11岁的摩根种公马被诊断患有累及消化道的系统性淀粉样变。该疾病的临床特征为体重减轻、流涎、贫血、持续性成熟中性粒细胞增多、低白蛋白血症和高球蛋白血症。D-木糖吸收试验表明存在吸收不良。尸检发现口腔、食管和胃溃疡，小肠黏膜发红并有少量出血。显微镜检查显示，除浆膜外，消化道所有组织层均发现淀粉样沉积。淀粉样沉积在小肠黏膜和黏膜下动脉最为明显。脾脏和淋巴结也有淀粉样物质，肝脏、肾脏、肺、胰腺和骨髓中的淀粉样物质较少。所有淀粉样沉积物经高锰酸钾-刚果红染色法对AA淀粉样蛋白呈典型组织化学反应，采用过氧化物酶-抗过氧化物酶技术用抗犬和抗牛蛋白AA抗血清证明了免疫组织化学交叉反应性。尽管血液学和血清学数据与潜在的慢性炎症过程相符，但淀粉样变的病因尚未确定。
