Fu Wei, Xu Shanshan, Dong Xiang, Xie Qing, Gao Yadong
Department of Allergology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, People's Republic of China.
J Asthma Allergy. 2021 Mar 9;14:201-205. doi: 10.2147/JAA.S292567. eCollection 2021.
Aspirin is clinically widely used to inhibit platelet aggregation after coronary intervention. Herein we describe a case of aspirin-induced thrombocytopenia that may be related to allergy to aspirin. A 47-year-old man developed a delayed hypersensitivity reaction to aspirin, with pruritus, purpura and thrombocytopenia, increased peripheral blood eosinophils and enlarged inguinal lymph node. All the symptoms disappeared in 2 years after stopping aspirin. Aspirin-induced thrombocytopenia related to allergy is rarely reported. Aspirin hypersensitivity should be taken into consideration in case of unexplained thrombocytopenia in patients taking aspirin. Aspirin "allergy"-induced thrombocytopenia may involve both aspirin related IgG and IgE antibodies.
阿司匹林在临床上广泛用于抑制冠状动脉介入术后的血小板聚集。在此，我们描述一例可能与阿司匹林过敏相关的阿司匹林诱导的血小板减少症。一名47岁男性对阿司匹林发生迟发型超敏反应，伴有瘙痒、紫癜和血小板减少，外周血嗜酸性粒细胞增多及腹股沟淋巴结肿大。停用阿司匹林后2年内所有症状消失。与过敏相关的阿司匹林诱导的血小板减少症鲜有报道。服用阿司匹林的患者出现不明原因的血小板减少时，应考虑阿司匹林超敏反应。阿司匹林“过敏”诱导的血小板减少症可能涉及与阿司匹林相关的IgG和IgE抗体。
