Korenberg R, Penneys N S, Kowalczyk A, Nadji M
Department of Dermatology, University of Miami School of Medicine, Florida.
J Cutan Pathol. 1988 Apr;15(2):104-8. doi: 10.1111/j.1600-0560.1988.tb00528.x.
Langerhans cells (LC) were identified and quantitated in non-inflamed keratoacanthoma (KA), inflamed KA, non-inflamed squamous cell carcinoma (SCC), and inflamed SCC, by their content of S100 protein. The number of LCs per high-power field was markedly increased in inflamed KA when compared to the other groups. Using similar methods on frozen sections, the expression of HLA-DR was identified on keratinocytes in KA in areas of inflammation but not in other lesions under study. We hypothesize that increased numbers of LCs in inflamed KA are part of the process which results in tumor regression.
通过S100蛋白含量，在非炎症性角化棘皮瘤（KA）、炎症性KA、非炎症性鳞状细胞癌（SCC）和炎症性SCC中鉴定并定量朗格汉斯细胞（LC）。与其他组相比，炎症性KA中每高倍视野的LC数量显著增加。在冰冻切片上使用类似方法，在炎症区域的KA角质形成细胞上鉴定出HLA-DR的表达，但在其他研究病变中未发现。我们推测，炎症性KA中LC数量增加是导致肿瘤消退过程的一部分。
