Ulutaş Firdevs, Çomut Erdem, Çobankara Veli
Division of Rheumatology, Department of Internal Medicine, Pamukkale University Faculty of Medicine, Denizli, Turkey.
Department of Pathology, Pamukkale University Faculty of Medicine, Denizli, Turkey.
Case Rep Oncol Med. 2021 Feb 26;2021:6628671. doi: 10.1155/2021/6628671. eCollection 2021.
Systemic sclerosis (SSc) is an uncommon rheumatic disease in which the underlying main histopathologic feature is a thickening of the skin due to excessive accumulation of collagen in the extracellular tissue. Fibrogenesis, chronic inflammation, and ulceration may eventually promote skin neoplasms. Although nonmelanoma skin cancer (NMSC) is the most frequent type, there have been restricted case reports and case series with skin cancers in SSc patients in the literature. Herein, we describe a 78-year-old woman diagnosed with diffuse cutaneous systemic sclerosis thirteen years ago and associated nonspecific interstitial pneumonia that was successfully treated with high cumulative doses of cyclophosphamide. She developed basal cell carcinoma and squamous cell carcinoma of the skin in the follow-up. She is still on rituximab treatment with stable interstitial lung disease as indicated by pulmonary function tests and high-resolution chest computed tomography. To our knowledge and a literature search, this is the first reported patient with SSc with two types of skin cancer. In this review, we also aimed to emphasize the relationship between SSc and skin cancer, and possible risk factors for SSc-related skin cancer.
系统性硬化症（SSc）是一种罕见的风湿性疾病，其主要组织病理学特征是细胞外组织中胶原蛋白过度积累导致皮肤增厚。纤维生成、慢性炎症和溃疡最终可能促进皮肤肿瘤的发生。尽管非黑色素瘤皮肤癌（NMSC）是最常见的类型，但文献中关于SSc患者皮肤癌的病例报告和病例系列有限。在此，我们描述了一名78岁女性，13年前被诊断为弥漫性皮肤系统性硬化症，并伴有非特异性间质性肺炎，曾接受高累积剂量环磷酰胺治疗且取得成功。在随访中，她发生了皮肤基底细胞癌和鳞状细胞癌。根据肺功能测试和高分辨率胸部计算机断层扫描结果，她仍在接受利妥昔单抗治疗，间质性肺病病情稳定。据我们所知及文献检索，这是首例报道的患有两种皮肤癌的SSc患者。在本综述中，我们还旨在强调SSc与皮肤癌之间的关系以及SSc相关皮肤癌的可能危险因素。
