Rufus-Membere Pamela, Holloway-Kew Kara L, Diez-Perez Adolfo, Kotowicz Mark A, Pasco Julie A
Deakin University, IMPACT - Institute for Mental and Physical Health and Clinical Translation, Geelong, VIC, Australia.
Department of Internal Medicine, Hospital del Mar-IMIM, Autonomous University of Barcelona and CIBERFES, Instituto Carlos III, Barcelona, Spain.
J Endocr Soc. 2020 Nov 22;5(4):bvaa179. doi: 10.1210/jendso/bvaa179. eCollection 2021 Apr 1.
Impact micro-indentation (IMI) measures bone material strength index (BMSi) in vivo. This study investigated how IMI is associated with calcaneal quantitative ultrasound and bone densitometry parameters in men.
BMSi was measured on the tibial plateau using the OsteoProbe in 377 men (age 33-96 years) from the Geelong Osteoporosis Study. Broadband ultrasound attenuation (BUA), speed of sound (SOS), and stiffness index (SI) were assessed at the calcaneus using an ultrasonometer. Areal BMD was measured at several skeletal sites using dual-energy x-ray absorptiometry. Linear associations between parameters were tested using Pearson's correlation. Multivariable regression techniques were used to determine associations between BMSi and other measures of bone, independent of confounders.
BMSi was negatively correlated with age (r = -0.171, = .001), weight (r = -0.100, = .052), and body mass index (r = -0.187, = .001), and positively with height (r = +0.109, = .034). There was some evidence to support a positive association between BMSi and BUA (β = 0.052, = .037), SOS (β = 0.013, = .144), and SI (β = 0.036, = .051). After age adjustment, this association was attenuated. No correlations were observed between BMSi and BMD at any skeletal site (r values ranged from -0.006 to +0.079, all ≥ .13).
There was a small positive association between BMSi and quantitative ultrasound (QUS) parameters, which were not independent of age. No associations were detected between BMSi and BMD. This suggests that BMSi and QUS are capturing common age-dependent properties of bone. Further research on the utility of IMI alone and complementary to conventional bone testing methods for predicting fracture risk is warranted.
冲击微压痕法（IMI）可在体内测量骨材料强度指数（BMSi）。本研究调查了男性中IMI与跟骨定量超声及骨密度测量参数之间的关联。
在来自吉朗骨质疏松症研究的377名男性（年龄33 - 96岁）中，使用OsteoProbe在胫骨平台测量BMSi。使用超声仪评估跟骨的宽带超声衰减（BUA）、声速（SOS）和硬度指数（SI）。使用双能X线吸收法在多个骨骼部位测量面积骨密度（BMD）。使用Pearson相关性检验参数之间的线性关联。采用多变量回归技术确定BMSi与其他骨测量指标之间的关联，独立于混杂因素。
BMSi与年龄呈负相关（r = -0.171，P = 0.001）、与体重呈负相关（r = -0.100，P = 0.052）、与体重指数呈负相关（r = -0.187，P = 0.001），与身高呈正相关（r = +0.109，P = 0.034）。有一些证据支持BMSi与BUA（β = 0.052，P = 0.037）、SOS（β = 0.013，P = 0.144）和SI（β = 0.036，P = 0.051）之间存在正相关。年龄调整后，这种关联减弱。在任何骨骼部位，均未观察到BMSi与BMD之间存在相关性（r值范围为 -0.006至 +0.079，所有P≥0.13）。
BMSi与定量超声（QUS）参数之间存在小的正相关，且这种相关性并非独立于年龄。未检测到BMSi与BMD之间存在关联。这表明BMSi和QUS正在捕捉骨骼的常见年龄依赖性特性。有必要进一步研究单独使用IMI以及与传统骨检测方法互补用于预测骨折风险的效用。
