Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Geelong, Australia.
Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Geelong, Australia.
Bone. 2022 Feb;155:116268. doi: 10.1016/j.bone.2021.116268. Epub 2021 Nov 29.
Bone material strength index (BMSi) is measured in vivo using impact microindentation (IMI). However, the associations between BMSi and other bone measures are not clear. This study investigated whether bone parameters derived by peripheral quantitative computed tomography (pQCT) are associated with BMSi.
Participants were men (n = 373, ages 34-96 yr) from the Geelong Osteoporosis Study. BMSi was measured using an OsteoProbe (Active Life Scientific, USA). Bone measures were obtained at both the radius (n = 348) and tibia (n = 342) using pQCT (XCT 2000 Stratec Medizintechnik, Germany). Images were obtained at 4% and 66% of radial and tibial length. Associations between pQCT parameters and BMSi were tested using Spearman's correlation and multivariable regression used to determine independent associations after adjustment for potential confounders. Models were checked for interaction terms.
Weak associations were observed between total bone density (radius 4%; r = +0.108, p = 0.046, tibia 4%; r = +0.115, p = 0.035), cortical density (tibia 4%; r = +0.123, p = 0.023) and BMSi. The associations were independent of weight, height, and glucocorticoid use (total bone density: radius 4%; β = 0.020, p = 0.006, tibia 4%; β = 0.020, p = 0.027 and cortical density: radius 4%; β = 4.160, p = 0.006, tibia 4%; β = 0.038, p = 0.010). Associations with bone mass were also observed at the 66% radial and tibial site, independent of age, weight, and glucocorticoid use (β = 4.160, p = 0.053, β = 1.458, p = 0.027 respectively). Total area at the 66% tibial site was also associated with BMSi (β = 0.010, p = 0.012), independent of weight and glucocorticoid use. No interaction terms were identified.
There were weak associations detected between some pQCT-derived bone parameters and BMSi.
骨材料强度指数（BMSi）通过冲击微压痕（IMI）在体内测量。然而，BMSi 与其他骨测量值之间的关系尚不清楚。本研究旨在探讨外周定量计算机断层扫描（pQCT）得出的骨参数是否与 BMSi 相关。
参与者为来自 Geelong 骨质疏松研究的男性（n=373，年龄 34-96 岁）。使用 OsteoProbe（美国 Active Life Scientific）测量 BMSi。使用 XCT 2000 Stratec Medizintechnik（德国）在桡骨（n=348）和胫骨（n=342）上获得骨测量值。图像分别在桡骨和胫骨长度的 4%和 66%处获得。使用 Spearman 相关检验检测 pQCT 参数与 BMSi 之间的相关性，使用多变量回归在调整潜在混杂因素后确定独立相关性。检查模型是否存在交互项。
在桡骨 4%处总骨密度（r=+0.108，p=0.046）和胫骨 4%处总骨密度（r=+0.115，p=0.035）、皮质骨密度（r=+0.123，p=0.023）与 BMSi 之间存在弱相关性。这些相关性独立于体重、身高和糖皮质激素的使用（桡骨 4%处总骨密度：β=0.020，p=0.006，胫骨 4%处总骨密度：β=0.020，p=0.027；桡骨 4%处皮质骨密度：β=4.160，p=0.006，胫骨 4%处皮质骨密度：β=0.038，p=0.010）。在桡骨和胫骨 66%处，与骨量相关的关联也独立于年龄、体重和糖皮质激素的使用（β=4.160，p=0.053；β=1.458，p=0.027）。胫骨 66%处的总面积也与 BMSi 相关（β=0.010，p=0.012），独立于体重和糖皮质激素的使用。未发现交互项。
本研究检测到一些 pQCT 衍生的骨参数与 BMSi 之间存在微弱的相关性。
