Am J Epidemiol. 2021 Sep 1;190(9):1821-1829. doi: 10.1093/aje/kwab074.
Present shift work has been associated with coronary heart disease (CHD) among employed workers, but it remains unclear whether shift work performed in the past is still associated with CHD in retired workers. We recruited 21,802 retired workers in Shiyan, China, in 2008-2010 and 2013 and followed them for CHD events occurring up to December 31, 2018. Retired workers with longer durations of past shift work (rounded to 0.25 years) had higher CHD risks (for those with ≤5.00, 5.25-10.00, 10.50-20.00, and >20.00 years of past shift work, hazard ratios were 1.05 (95% confidence interval (CI): 0.94, 1.16), 1.08 (95% CI: 0.94, 1.25), 1.23 (95% CI: 1.07, 1.42), and 1.28 (95% CI: 1.08, 1.51), respectively). The association was substantially higher among service or sales workers than among manufacturing or manual-labor workers (for every 5-year increase in past shift work, hazard ratio = 1.11 (95% CI: 1.05, 1.16) vs. hazard ratio = 1.02 (95% CI: 0.98, 1.06)). Moreover, the risk was lower among those who were physically active than among their inactive counterparts (P for interaction = 0.019). Longer duration of past shift work was associated with higher risk of incident CHD among these retired workers, especially those from the service or sales sectors. Physical exercise might be beneficial in reducing the excess risk.
目前的轮班工作与在职员工的冠心病（CHD）有关，但过去的轮班工作是否仍与退休工人的 CHD 有关尚不清楚。我们于 2008-2010 年和 2013 年在十堰招募了 21802 名退休工人，并对他们进行了随访，直到 2018 年 12 月 31 日发生 CHD 事件。过去轮班工作时间较长的退休工人（四舍五入至 0.25 年）发生 CHD 的风险更高（对于过去轮班工作时间≤5.00、5.25-10.00、10.50-20.00 和>20.00 年的工人，风险比分别为 1.05（95%置信区间（CI）：0.94，1.16）、1.08（95% CI：0.94，1.25）、1.23（95% CI：1.07，1.42）和 1.28（95% CI：1.08，1.51））。与制造业或体力劳动工人相比，服务或销售人员的这种关联更为显著（过去轮班工作每增加 5 年，风险比=1.11（95% CI：1.05，1.16）比风险比=1.02（95% CI：0.98，1.06））。此外，与不活跃的工人相比，活跃的工人的风险较低（交互作用 P 值=0.019）。过去轮班工作时间较长与这些退休工人发生冠心病事件的风险较高有关，尤其是来自服务或销售部门的工人。体育锻炼可能有益于降低这种风险。
