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Anti-inflammatory potential of Empagliflozin.

作者信息

Pirklbauer Markus

机构信息

Department of Internal Medicine IV-Nephrology and Hypertension, Medical University Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.

出版信息

Inflammopharmacology. 2021 Apr;29(2):573-576. doi: 10.1007/s10787-021-00797-9. Epub 2021 Mar 17.

DOI:10.1007/s10787-021-00797-9
PMID:33728540
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7997819/
Abstract
摘要

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本文引用的文献

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Empagliflozin Inhibits Basal and IL-1β-Mediated MCP-1/CCL2 and Endothelin-1 Expression in Human Proximal Tubular Cells.恩格列净抑制人近端肾小管细胞基础状态及白介素-1β介导的单核细胞趋化蛋白-1/CCL2 和内皮素-1 的表达。
Int J Mol Sci. 2020 Nov 1;21(21):8189. doi: 10.3390/ijms21218189.
2
Dapagliflozin in Patients with Chronic Kidney Disease.达格列净治疗慢性肾脏病患者。
N Engl J Med. 2020 Oct 8;383(15):1436-1446. doi: 10.1056/NEJMoa2024816. Epub 2020 Sep 24.
3
Empagliflozin suppresses inflammation and protects against acute septic renal injury.恩格列净可抑制炎症反应，防止急性脓毒症肾损伤。
Inflammopharmacology. 2021 Feb;29(1):269-279. doi: 10.1007/s10787-020-00732-4. Epub 2020 Jun 20.
4
The tubular hypothesis of nephron filtration and diabetic kidney disease.管状假说在肾单位滤过和糖尿病肾病中的作用。
Nat Rev Nephrol. 2020 Jun;16(6):317-336. doi: 10.1038/s41581-020-0256-y. Epub 2020 Mar 9.
5
Sodium-glucose cotransporter 2 inhibition: towards an indication to treat diabetic kidney disease.钠-葡萄糖共转运蛋白 2 抑制剂：治疗糖尿病肾病的新靶点。
Nephrol Dial Transplant. 2020 Jan 1;35(Suppl 1):i13-i23. doi: 10.1093/ndt/gfz237.
6
Empagliflozin Blunts Worsening Cardiac Dysfunction Associated With Reduced NLRP3 (Nucleotide-Binding Domain-Like Receptor Protein 3) Inflammasome Activation in Heart Failure.恩格列净可减轻心力衰竭相关的 NLRP3（核苷酸结合寡聚化结构域样受体蛋白 3）炎症小体激活导致的心脏功能恶化。
Circ Heart Fail. 2020 Jan;13(1):e006277. doi: 10.1161/CIRCHEARTFAILURE.119.006277. Epub 2020 Jan 20.
7
Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction.达格列净治疗射血分数降低的心力衰竭患者。
N Engl J Med. 2019 Nov 21;381(21):1995-2008. doi: 10.1056/NEJMoa1911303. Epub 2019 Sep 19.
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Interleukin-1β Inhibition for Chronic Kidney Disease in Obese Mice With Type 2 Diabetes.白细胞介素-1β 抑制肥胖 2 型糖尿病小鼠的慢性肾脏病。
Front Immunol. 2019 May 29;10:1223. doi: 10.3389/fimmu.2019.01223. eCollection 2019.
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Canagliflozin reduces inflammation and fibrosis biomarkers: a potential mechanism of action for beneficial effects of SGLT2 inhibitors in diabetic kidney disease.卡格列净可降低炎症和纤维化生物标志物：SGLT2 抑制剂在糖尿病肾病中有益作用的潜在作用机制。
Diabetologia. 2019 Jul;62(7):1154-1166. doi: 10.1007/s00125-019-4859-4. Epub 2019 Apr 17.
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Unraveling reno-protective effects of SGLT2 inhibition in human proximal tubular cells.解析 SGLT2 抑制在人近端肾小管细胞中的肾保护作用。
Am J Physiol Renal Physiol. 2019 Mar 1;316(3):F449-F462. doi: 10.1152/ajprenal.00431.2018. Epub 2018 Dec 12.