Radiology Department, Capital Medical University Affiliated Beijing Friendship Hospital, Beijing, China.
J Magn Reson Imaging. 2021 Jul;54(1):146-153. doi: 10.1002/jmri.27548. Epub 2021 Mar 16.
Metabolic syndrome increases the risk of chronic diseases such as cardiovascular disease and diabetes. Metabolic syndrome also has an impact on bone mineral density. However, the relationship between metabolic syndrome and bone marrow fat is unclear.
To determine factors associated with bone marrow fat concentration in subjects with and without metabolic syndrome.
Retrospective.
One hundred and one women with metabolic syndrome (31.0 years ±5.1) and 96 female living liver transplant donors (32.0 years ±3.7). Our institutional review board approved the study. Each subject signed written informed consent.
FIELD STRENGTH/SEQUENCE: 3.0 T MRI system and a commercially available chemical shift-encoded 3D sequence (Iterative Decomposition of water and fat with Echo asymmetry and Least Square Estimation).
Proton density fat fraction (PDFF) in liver, vertebral body, and paraspinal muscle (erector spinae) were measured from a single acquisition by a 15-year-experience orthopedic radiologist. The factors associated with PDFF were acquired.
The analysis of covariance test, after adjustment for body mass index and age, was used to analyze the differences between metabolic syndrome and non-metabolic syndrome groups. A stepwise multiple regression analysis was used to determine which variables were independently associated with PDFF.
Mean vertebral PDFF and alanine aminotransferase (ALT) were significantly lower in donors than subjects with metabolic syndrome (both P < 0.05). Serum vitamin D concentration, ferritin, and high-density lipoprotein (HDL) cholesterol were significantly higher in donors than subjects with metabolic syndrome (all P < 0.05). Multiple regression analysis revealed antidiabetic medicine, higher serum vitamin D concentration, lower waist circumference, lower ferritin, lower HDL, absence of metabolic syndrome, and lower ALT were significantly associated with lower vertebral PDFF (all P < 0.05).
Multiple factors affect bone marrow fat concentration in subjects with metabolic syndrome. Serum vitamin D concentration and antidiabetic medicine are associated with low bone marrow fat, whereas waist circumference, serum ferritin, metabolic syndrome, imbalanced lipid metabolism, and abnormal liver function are associated with high bone marrow fat.
3 TECHNICAL EFFICACY STAGE: 1.
代谢综合征会增加患心血管疾病和糖尿病等慢性病的风险。代谢综合征还会影响骨髓脂肪密度。然而，代谢综合征与骨髓脂肪之间的关系尚不清楚。
确定患有和不患有代谢综合征的受试者中与骨髓脂肪浓度相关的因素。
回顾性研究。
101 名患有代谢综合征的女性（31.0±5.1 岁）和 96 名女性活体肝移植供体（32.0±3.7 岁）。我们的机构审查委员会批准了这项研究。每位受试者均签署了书面知情同意书。
场强/序列：3.0T MRI 系统和商业上可用的化学位移编码 3D 序列（通过水和脂肪的迭代分解与回波不对称和最小二乘估计）。
由一位具有 15 年经验的骨科放射科医生从单次采集测量肝、椎体和脊柱旁肌肉（竖脊肌）的质子密度脂肪分数（PDFF）。获取与 PDFF 相关的因素。
采用协方差分析检验，在调整体重指数和年龄后，分析代谢综合征组和非代谢综合征组之间的差异。采用逐步多元回归分析确定哪些变量与 PDFF 独立相关。
供体的平均椎体 PDFF 和丙氨酸氨基转移酶（ALT）显著低于代谢综合征患者（均 P<0.05）。供体的血清维生素 D 浓度、铁蛋白和高密度脂蛋白（HDL）胆固醇显著高于代谢综合征患者（均 P<0.05）。多元回归分析显示，降糖药、较高的血清维生素 D 浓度、较低的腰围、较低的铁蛋白、较低的 HDL、无代谢综合征和较低的 ALT 与较低的椎体 PDFF 显著相关（均 P<0.05）。
多种因素影响代谢综合征患者的骨髓脂肪浓度。血清维生素 D 浓度和降糖药与低骨髓脂肪相关，而腰围、血清铁蛋白、代谢综合征、脂质代谢失衡和肝功能异常与高骨髓脂肪相关。
3 级 技术功效等级：1 级
