Öksüz Özden, Günver Mehmet Güven, Arıkan Mehmet Kemal
Department of Neuroscience, 52998Yeditepe University, İstanbul, Turkey.
232990Department of Biostatistics, İstanbul University, İstanbul, Turkey.
Clin EEG Neurosci. 2022 May;53(3):248-255. doi: 10.1177/1550059421997657. Epub 2021 Mar 17.
. Diabetes mellitus (DM) causes structural central nervous system (CNS) impairment, and this situation can be detected by quantitative electroencephalography (QEEG) findings before cognitive impairment is clinically observed. The main aim of this study is to uncover the effect of DM on brain function. Since QEEG reflects the CNS functioning, particularly in cognitive aspects, we expected electrophysiological clues to be found for prevention and follow-up in DM-related cognitive decline. Since a majority of the psychiatric population have cognitive dysfunction, we have given particular attention to those people. It was stated that a decrease was observed in the posterior cortical alpha power due to the hippocampal atrophy by several previous studies and we hypothesize that decreased alpha power will be observed also in DM. . This study included 2094 psychiatric patients, 207 of whom were diagnosed with DM and 1887 of whom were not diagnosed with DM, and QEEG recordings were performed. Eyes-closed electroencephalography data were segmented into consecutive 2 s epochs. Fourier analysis was performed by averaging across 2 s epochs without artifacts. The absolute alpha power in the occipital regions (O1 and O2) of patients with and without DM was compared. . In the DM group, a decrease in the absolute alpha, alpha 1, and alpha 2 power in O1 and O2 was observed in comparison with the control group. It was determined that the type of psychiatric diagnosis did not affect QEEG findings. . The decrease in absolute alpha power observed in patients diagnosed with DM may be related to the CNS impairment in DM. QEEG findings in DM can be useful while monitoring the CNS impairment, diagnosing DM-related dementia, in the follow-up of the cognitive process, constructing the protocols for electrophysiological interventions like neurofeedback and transcranial magnetic stimulation and monitoring the response to treatment.
糖尿病（DM）会导致中枢神经系统（CNS）结构损伤，并且这种情况在临床观察到认知损伤之前，可通过定量脑电图（QEEG）结果检测出来。本研究的主要目的是揭示DM对脑功能的影响。由于QEEG反映中枢神经系统功能，尤其是在认知方面，我们期望能找到电生理线索，用于DM相关认知衰退的预防和随访。由于大多数精神疾病患者存在认知功能障碍，我们对这些人群给予了特别关注。先前的几项研究表明，由于海马萎缩，后皮质α波功率下降，我们推测DM患者也会出现α波功率下降。本研究纳入了2094名精神科患者，其中207名被诊断为DM，1887名未被诊断为DM，并进行了QEEG记录。闭眼脑电图数据被分割为连续的2秒时段。通过对无伪迹的2秒时段进行平均来进行傅里叶分析。比较了DM患者和非DM患者枕区（O1和O2）的绝对α波功率。与对照组相比，DM组O1和O2的绝对α波、α1波和α2波功率下降。确定精神科诊断类型不影响QEEG结果。诊断为DM的患者中观察到的绝对α波功率下降可能与DM中的中枢神经系统损伤有关。DM的QEEG结果在监测中枢神经系统损伤、诊断DM相关痴呆、认知过程随访、构建神经反馈和经颅磁刺激等电生理干预方案以及监测治疗反应方面可能会有帮助。
