Espiritu B R, Szpindor-Watson A, Zeitz H J, Thomas L L
Department of Immunology/Microbiology, Rush Medical College, Chicago, IL 60612.
J Allergy Clin Immunol. 1988 May;81(5 Pt 1):847-51. doi: 10.1016/0091-6749(88)90941-4.
Persistent Trichophyton rubrum infection has been observed previously in association with Cushing's syndrome. In this article, we demonstrate IgE-mediated sensitivity to Trichophyton in a patient with chronic dermatophytosis secondary to Cushing's syndrome. Cell-mediated immunity was absent, but Trichophyton extract produced an immediate skin response and also stimulated a concentration-dependent histamine release from basophils of the patient. After adrenalectomy, cell-mediated immunity to Trichophyton was restored, and infection was confined to the nails. Skin and leukocyte sensitivity to Trichophyton extract persisted and was even more pronounced than the sensitivity before adrenalectomy. RAST measurement confirmed the presence of Trichophyton-specific IgE after adrenalectomy. These results provide further evidence that IgE-mediated inflammatory events may be initiated by Trichophyton infection.
先前已观察到持续性红色毛癣菌感染与库欣综合征有关。在本文中，我们证明了一名继发于库欣综合征的慢性皮肤癣菌病患者对红色毛癣菌存在IgE介导的敏感性。细胞介导的免疫反应缺失，但红色毛癣菌提取物引起了即时皮肤反应，并且还刺激了患者嗜碱性粒细胞释放浓度依赖性组胺。肾上腺切除术后，对红色毛癣菌的细胞介导免疫得以恢复，感染局限于指甲。皮肤和白细胞对红色毛癣菌提取物的敏感性持续存在，甚至比肾上腺切除术前更为明显。放射变应原吸附试验测量证实肾上腺切除术后存在红色毛癣菌特异性IgE。这些结果进一步证明IgE介导的炎症事件可能由红色毛癣菌感染引发。
