Chemometrics in forensic science: approaches and applications.

Forensic investigations are often reliant on physical evidence to reconstruct events surrounding a crime. However, there remains a need for more objective approaches to evidential interpretation, along with rigorously validated procedures for handling, storage and analysis. Chemometrics has been recognised as a powerful tool within forensic science for interpretation and optimisation of analytical procedures. However, careful consideration must be given to factors such as sampling, validation and underpinning study design. This tutorial review aims to provide an accessible overview of chemometric methods within the context of forensic science. The review begins with an overview of selected chemometric techniques, followed by a broad review of studies demonstrating the utility of chemometrics across various forensic disciplines. The tutorial review ends with the discussion of the challenges and emerging trends in this rapidly growing field.