Departamento de Puericultura e Pediatria, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.
Departamento de Genética, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.
Braz J Med Biol Res. 2021 Mar 10;54(1):e10465. doi: 10.1590/1414-431X202010465. eCollection 2021.
Intrauterine growth restriction (IUGR) is related to a higher risk of neonatal mortality, minor cognitive deficit, metabolic syndrome, and cardiovascular disease in adulthood. In previous studies, genetic variants in the FTO (fat mass and obesity-associated) and PPARγ (peroxisome proliferator-activated receptor-gamma) genes have been associated with metabolic disease, body mass index, and obesity among other outcomes. We studied the association of selected FTO (rs1421085, rs55682395, rs17817449, rs8043757, rs9926289, and rs9939609) and PPARγ (rs10865710, rs17036263, rs35206526, rs1801282, rs28763894, rs41516544, rs62243567, rs3856806, and rs1805151) single-nucleotide polymorphisms (SNPs) with IUGR, through a case-control study in a cohort of live births that occurred from June 1978 to May 1979 in a Brazilian city. We selected 280 IUGR cases and 256 controls for analysis. Logistic regression was used to jointly analyze the SNPs as well as factors such as maternal smoking, age, and schooling. We found that the PPARγ rs41516544 increased the risk of IUGR for male offspring (OR 27.83, 95%CI 3.65-212.32) as well as for female offspring (OR=8.94, 95%CI: 1.96-40.88). The FTO rs9939609 TA genotype resulted in a reduced susceptibility to IUGR for male offspring only (OR=0.47, 95%CI: 0.26-0.86). In conclusion, we demonstrated that PPARγ SNP had a positive effect and FTO SNP had a negative effect on IUGR occurrence, and these effects were gender-specific.
宫内生长受限 (IUGR) 与新生儿死亡率升高、认知功能轻微缺陷、代谢综合征和成年人心血管疾病风险增加有关。在之前的研究中，FTO（脂肪质量和肥胖相关）和 PPARγ（过氧化物酶体增殖物激活受体-γ）基因的遗传变异与代谢疾病、体重指数和肥胖等结果有关。我们研究了选定的 FTO（rs1421085、rs55682395、rs17817449、rs8043757、rs9926289 和 rs9939609）和 PPARγ（rs10865710、rs17036263、rs35206526、rs1801282、rs28763894、rs41516544、rs62243567、rs3856806 和 rs1805151）单核苷酸多态性 (SNP) 与 IUGR 的关系，通过对 1978 年 6 月至 1979 年 5 月在巴西一个城市出生的活产儿进行病例对照研究进行分析。我们选择了 280 例 IUGR 病例和 256 例对照进行分析。使用逻辑回归联合分析 SNP 以及母亲吸烟、年龄和教育程度等因素。我们发现，PPARγ rs41516544 增加了男性后代（OR 27.83，95%CI 3.65-212.32）和女性后代（OR=8.94，95%CI：1.96-40.88）IUGR 的风险。FTO rs9939609 TA 基因型仅使男性后代对 IUGR 的易感性降低（OR=0.47，95%CI：0.26-0.86）。总之，我们证明了 PPARγ SNP 对 IUGR 的发生有积极影响，FTO SNP 有消极影响，且这些影响具有性别特异性。
