Department of Clinical Neurosciences, Division of Eye and Vision, St. Erik Eye Hospital, Karolinska Institutet, Stockholm, Sweden.
Acta Ophthalmol. 2021 Dec;99(8):e1255-e1262. doi: 10.1111/aos.14845. Epub 2021 Mar 17.
Ocular neovascular diseases, such as proliferative diabetic retinopathy, retinopathy of prematurity and neovascular age-related macular degeneration, are the leading causes of visual impairment worldwide. The hypoxia-inducible factors and vascular endothelial growth factors are key molecular promoters of ocular neovascularization. Moreover, the role of microRNAs as regulators of angiogenesis has been expanding, particularly hypoxia-associated microRNA; hypoxamiRs. This review provides a summary of hypoxamiRs that directly and specifically target HIF1A and VEGF mRNAs, thus critically involved in the regulation of ocular neovascular pathologies. The discussed microRNAs highlight putative diagnostic markers and therapeutic agents in choroidal and retinal angiogenic diseases, including proliferative diabetic retinopathy, retinopathy of prematurity and neovascular age-related macular degeneration.
眼部新生血管疾病，如增生性糖尿病视网膜病变、早产儿视网膜病变和新生血管性年龄相关性黄斑变性，是全球视力损害的主要原因。缺氧诱导因子和血管内皮生长因子是眼部新生血管形成的关键分子促进剂。此外，microRNAs 作为血管生成调节剂的作用不断扩大，特别是与缺氧相关的 microRNA；hypoxamiRs。本综述总结了直接和特异地针对 HIF1A 和 VEGF mRNAs 的 hypoxamiRs，这些 miRNAs 对眼部新生血管病变的调节起着至关重要的作用。讨论的 microRNAs 强调了脉络膜和视网膜血管生成性疾病，包括增生性糖尿病视网膜病变、早产儿视网膜病变和新生血管性年龄相关性黄斑变性中的潜在诊断标志物和治疗剂。
