Ahmadi Samaneh, Gohari-Lasaki Sahar, Jahangiri Negin, Ejlalidiz Mahsa, Saberiyan Mohammadreza
Department of Medical Genetics, Faculty of Medicine, School of Medical Sciences, Hormozgan University of Medical Sciences, P.O.Box: 7919693116, Bandar Abbas, Iran.
Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Mol Biol Rep. 2025 May 31;52(1):527. doi: 10.1007/s11033-025-10642-9.
The cornea, as the essential part of the eye with the duty of maintaining transparency and vision, is susceptible to various diseases and genetic abnormalities. Vision loss due to corneal disorders is a global concern, prompting research into innovative treatment approaches. The investigations have provided a significant role that exosomes play in maintaining corneal homeostasis and promoting intercellular communication. The cornea is made up of cellular and acellular components. The cellular components include the epithelial cells, stromal keratocytes, and endothelial cells, which secrete exosomes that contribute to preserving corneal transparency, immune privilege, and tissue repair. These nanosized vesicles contain molecules that regulate immune responses, promote cell proliferation and migration, and protect against stress-induced cell death. In this review, we try to survey the therapeutic potential and effects of exosomes in treating various corneal conditions, which can contribute to enhance corneal healing, reduce scarring, and improve visual outcomes.
角膜作为眼睛的重要组成部分，肩负着维持透明度和视力的职责，容易受到各种疾病和基因异常的影响。因角膜疾病导致的视力丧失是一个全球性问题，促使人们对创新治疗方法进行研究。研究表明外泌体在维持角膜内环境稳态和促进细胞间通讯方面发挥着重要作用。角膜由细胞和非细胞成分组成。细胞成分包括上皮细胞、基质角膜细胞和内皮细胞，它们分泌的外泌体有助于维持角膜透明度、免疫赦免和组织修复。这些纳米级囊泡含有调节免疫反应、促进细胞增殖和迁移以及防止应激诱导细胞死亡的分子。在这篇综述中，我们试图探讨外泌体在治疗各种角膜疾病方面的治疗潜力和效果，这有助于促进角膜愈合、减少瘢痕形成并改善视觉效果。
