Bhopale G M, Bhatnagar B S
Department of Zoology, Madhav Science College, Vikram University, Ujjain, India.
J Helminthol. 1988 Mar;62(1):40-4. doi: 10.1017/s0022149x00011184.
In an experimental larval infection of Ancylostoma caninum in mice, the efficacy of various anthelmintics against the larvae migrated and established in the brain is reported for the first time. Albendazole and flubendazole were the most effective drugs. Thiabendazole, benacil, phenacizole, oxfendazole and mebendazole showed significant larvicidal activity. Tetramisole, levamisole, fenbendazole, Sch 18099, pyrantel pamoate, morantel tartrate and oxantel pamoate did not show any significant activity even at relatively high dose levels.
在一项犬钩虫幼虫感染小鼠的实验中，首次报道了各种驱虫药对迁移至脑部并定居的幼虫的疗效。阿苯达唑和氟苯达唑是最有效的药物。噻苯达唑、贝那西尔、非那西唑、奥芬达唑和甲苯达唑表现出显著的杀幼虫活性。四咪唑、左旋咪唑、芬苯达唑、Sch 18099、吡喹酮、酒石酸噻嘧啶和奥克太尔即使在相对高剂量水平下也未表现出任何显著活性。
