Lämmler G, El-Gendi A Y
Z Parasitenkd. 1978 Dec 21;58(1):55-63. doi: 10.1007/BF00930792.
Investigations have been carried out on the multimammate rat (Mastomys natalensis), orally infected with 1000 third stage larvae of Ancylostoma caninum per animal, to evaluate the larvicidal efficacy of anthelmintics in this paratenic host. The oral or subcutaneous administration of 19 anthelmintics and filaricides revealed good activity for levamisole, cambendazole, and mebendazole against 15-day-old Ancylostoma larvae which were located in the muscular tissue. Similarly, good results were obtained with levamisole and cambendazole against the migrating third stage larvae, by treatment two to six days after infection. The benzimidazole derivatives, thiabendazole, oxibendazole, parbendazole, and fenbendazole showed marked activity only at high dosage rates. The anthelmintics methyridine, amoscanate, pyrantel tartrate, morantel tartrate; the microfilaricidal organophosphates dichlorvos, fenthion, and haloxon; as well as the micro- or macrofilaricidal drugs diethylcarbamazine, nitrofurantoin, nifurtimox, suramin sodium, and thiacetarsamide sodium failed to show larvicidal activity even in high dosages. The average larval recovery rate after oral infection with 1000 third stage larvae, in untreated control animals, was 14.85%.
已对每只经口感染1000条犬钩口线虫第三期幼虫的多乳鼠（南非多乳鼠）进行了研究，以评估驱虫药在这种转续宿主体内的杀幼虫效果。19种驱虫药和杀丝虫药的口服或皮下给药显示，左旋咪唑、坎苯达唑和甲苯达唑对位于肌肉组织中的15日龄犬钩口线虫幼虫具有良好活性。同样，感染后两至六天进行治疗，左旋咪唑和坎苯达唑对移行期第三期幼虫也取得了良好效果。苯并咪唑衍生物噻苯达唑、奥苯达唑、巴苯达唑和芬苯达唑仅在高剂量率时显示出显著活性。驱虫药甲噻嘧啶、硝硫氰胺、酒石酸噻嘧啶、噻嘧啶；杀微丝蚴有机磷酸酯敌敌畏、倍硫磷和氯磷定；以及杀微丝蚴或杀大丝蚴药物乙胺嗪、呋喃妥因、硝呋替莫、苏拉明钠和硫乙酰胂胺钠即使在高剂量时也未显示出杀幼虫活性。在未经治疗的对照动物中，经口感染1000条第三期幼虫后的平均幼虫回收率为14.85%。
