Sugane K
Department of Parasitology, Faculty of Medicine, Shinshu University, Nagano Prefecture, Japan.
J Helminthol. 1988 Mar;62(1):51-7. doi: 10.1017/s0022149x00011214.
The secondary response of eosinophilia has been studied in mice infected with A. suum. In mice infected orally with 1000 A. suum eggs, larvae disappeared from the body within two weeks after infection. The number of peripheral blood eosinophils decreased to the pre-infection level within eight weeks. A typical secondary response of IgG antibody production to egg antigen was found after reinfection with 1000 eggs. The number of peripheral blood eosinophils increased more rapidly after reinfection than after the primary infection. However, the peak number of eosinophils after reinfection was similar to that after primary infection, and the long-lasting characteristics of eosinophilia after reinfection did not differ from those after primary infection. These results suggest that the secondary response of eosinophilia is characterized by a rapid increase in the number of eosinophils in A. suum-reinfected mice.
已在感染猪蛔虫的小鼠中研究了嗜酸性粒细胞增多的二次反应。口服感染1000枚猪蛔虫卵的小鼠，感染后两周内幼虫从体内消失。外周血嗜酸性粒细胞数量在八周内降至感染前水平。再次感染1000枚虫卵后，发现对虫卵抗原产生了典型的IgG抗体产生二次反应。再次感染后外周血嗜酸性粒细胞数量的增加比初次感染后更快。然而，再次感染后嗜酸性粒细胞的峰值数量与初次感染后相似，再次感染后嗜酸性粒细胞增多的持久特征与初次感染后没有差异。这些结果表明，嗜酸性粒细胞增多的二次反应的特征是在再次感染猪蛔虫的小鼠中嗜酸性粒细胞数量迅速增加。
