Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Department of Oral Pathology, College of Stomatology, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Disease, Shanghai Ninth People's Hospital, Shanghai, China.
Department of Radiology, Shanghai Ninth People's Hospital, Shanghai, China.
J Oral Pathol Med. 2021 Aug;50(7):723-730. doi: 10.1111/jop.13168. Epub 2021 Mar 29.
Salivary gland extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue lymphoma (MALT lymphoma) is uncommon and has not been studied extensively. We aimed to investigate the features of clinicopathological and molecular changes of salivary MALT lymphoma.
Seventy-two cases of primary salivary MALT lymphoma that had clinicopathological information available were utilized in this study. MALT1 gene translocation, trisomy 3, and trisomy 18 were detected by interphase fluorescence in situ hybridization (FISH). The data were analyzed using SPSS 17.0 software package.
The ratio of male to female was 1:2.8, and the median age was 57.0 years. 12.5% (9/72) of the patients presented with multiple swellings. Among the others with solitary mass, the parotid gland was involved most frequently (47/63,74.6%), followed by the palate (7/63, 11.1%). 34.7% of patients had an autoimmune disease, with Sjögren syndrome (SS) being the most common. Among the 70 cases successfully performed, it was identified that trisomy 3 was the most frequent molecular change (41/70, 58.6%), followed by trisomy 18 (7/70, 10%) and MALT1 translocation (5/70, 7.1%). The tumor tissue tended to exhibit trisomy 3 in patients without SS (p = 0.038). The 5-year overall survival was 94.1%, and the 5-year disease-free survival was 85.3% (mean follow-up time: 104.7 months). The patients without SS and trisomy 18 had a prolonged recurrence-free survival (p = 0.015, p = 0.001 respectively).
Salivary gland MALT lymphoma is associated with autoimmune diseases, and trisomy 3 is the most common genetic change. Trisomy 18 can be used to predict the possibility of tumor relapse.
黏膜相关淋巴组织结外边缘区淋巴瘤（MALT 淋巴瘤）的涎腺外淋巴结发病率较低，尚未得到广泛研究。本研究旨在探讨涎腺 MALT 淋巴瘤的临床病理和分子变化特征。
本研究纳入了 72 例具有临床病理资料的原发性涎腺 MALT 淋巴瘤患者。采用间期荧光原位杂交（FISH）检测 MALT1 基因易位、三体 3 和三体 18。采用 SPSS 17.0 软件包进行数据分析。
男女性别比为 1:2.8，中位年龄为 57.0 岁。12.5%（9/72）的患者表现为多发性肿块。其余表现为单发肿块的患者中，最常累及的部位是腮腺（47/63，74.6%），其次是腭部（7/63，11.1%）。34.7%的患者存在自身免疫性疾病，其中干燥综合征（SS）最常见。在 70 例成功进行检测的病例中，最常见的分子改变是三体 3（41/70，58.6%），其次是三体 18（7/70，10%）和 MALT1 易位（5/70，7.1%）。在没有 SS 的患者中，肿瘤组织倾向于表现出三体 3（p=0.038）。5 年总生存率为 94.1%，5 年无病生存率为 85.3%（平均随访时间：104.7 个月）。没有 SS 和三体 18 的患者无复发生存时间更长（p=0.015，p=0.001）。
涎腺 MALT 淋巴瘤与自身免疫性疾病相关，三体 3 是最常见的遗传改变。三体 18 可用于预测肿瘤复发的可能性。
