Westchester Medical Center Health Network, Valhalla, NY, USA.
New York Medical College School of Medicine, Valhalla, NY, USA.
Hosp Pract (1995). 2021 Oct;49(4):255-261. doi: 10.1080/21548331.2021.1906012. Epub 2021 Mar 30.
Brugada syndrome (BrS) was initially described in southeast Asians with a structurally normal heart presenting with polymorphic ventricular tachycardia and fibrillation. This condition is marked by J-point elevation ≥ 2 mm with coved-type ST segment elevation followed by negative T wave inversions in at least one precordial lead (V1 or V2) when other etiologies have been excluded. These changes on electrocardiogram (EKG) can either be spontaneous or manifest after sodium channel blockade. The worldwide prevalence of BrS is about 0.4%; however, it is higher in the Asian population at 0.9%. This article will review the current hypotheses regarding the pathophysiology, spectrum of clinical presentation, strategies for prevention of sudden cardiac death and the treatment for recurrent arrhythmias in BrS.
Brugada 综合征（BrS）最初在东南亚人群中被描述，这些人群具有结构正常的心脏，表现为多形性室性心动过速和颤动。这种情况的特点是 J 点抬高≥2mm，伴有下斜型 ST 段抬高，随后在前胸导联（V1 或 V2）至少出现一个负向 T 波倒置，排除其他病因。这些心电图（EKG）改变可以是自发性的，也可以在钠通道阻断后表现出来。BrS 的全球患病率约为 0.4%；然而，在亚洲人群中患病率更高，为 0.9%。本文将综述 BrS 的病理生理学、临床表现谱、预防心源性猝死的策略以及治疗复发性心律失常的当前假说。
