Division of Gastroenterology, Hospital Beatriz Ângelo, Loures, Portugal.
Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
J Crohns Colitis. 2021 Sep 25;15(9):1443-1454. doi: 10.1093/ecco-jcc/jjab048.
Inflammatory bowel disease [IBD] is a complex chronic disorder with no clear aetiology and no known cure. Despite recent advances in overall disease management and improved therapeutics, patients with IBD still experience a substantial burden. Furthermore, as the incidence continues to increase in developing areas of the world, it is expected that the burden of IBD to society will increase and exert tremendous pressure on health care systems worldwide. Therefore, new strategies to prevent the global increase of IBD are urgently required. Data are being progressively acquired on the period preceding disease diagnosis, which support the concept that IBD has a preclinical period that may reveal the triggers of disease and may be amenable to early intervention. Having a better knowledge of this preclinical period will increase the potential not only for improved understanding of disease pathogenesis and improved therapeutics, but also for disease prediction and prevention.
炎症性肠病(IBD)是一种复杂的慢性疾病,病因尚不明确,也没有已知的治愈方法。尽管近年来在疾病整体管理和治疗方法的改进方面取得了进展,但 IBD 患者仍面临着巨大的负担。此外,随着世界发展中地区的发病率持续上升,预计 IBD 给社会带来的负担将会增加,并对全球卫生保健系统造成巨大压力。因此,迫切需要制定新的策略来预防 IBD 的全球增长。在疾病诊断前的时期,人们正在逐步获得数据,这些数据支持 IBD 具有临床前阶段的概念,这可能揭示疾病的触发因素,并可能对早期干预有效。更好地了解这一临床前阶段不仅将增加对疾病发病机制和治疗方法的更好理解的潜力,而且还将增加疾病预测和预防的潜力。