University Hospitals Leuven Department of Gastroenterology and Hepatology, KU Leuven, Leuven, Belgium.
KU Leuven Department of Chronic Diseases and Metabolism, Translational Research Center for Gastrointestinal Disorders [TARGID], Leuven, Belgium.
J Crohns Colitis. 2021 Sep 25;15(9):1431-1442. doi: 10.1093/ecco-jcc/jjab050.
Inflammatory bowel diseases [IBD] are a heterogeneous spectrum with two extreme phenotypes, Crohn's disease [CD] and ulcerative colitis [UC], which both represent numerous phenotypical variations. Hence, we should no longer approach all IBD patients similarly, but rather aim to rethink clinical classifications and modify treatment algorithms to usher in a new era of precision medicine in IBD. This scientific ECCO workshop aims to provide a state-of-the-art overview on prognostic and predictive markers, shed light on key questions in biomarker development, propose best practices in IBD biomarker development [including trial design], and discuss the potential for multi-omic data integration to help drive further advances to make precision medicine a reality in IBD.
炎症性肠病（IBD）是一个具有两个极端表型的异质谱，即克罗恩病（CD）和溃疡性结肠炎（UC），它们都代表了许多表型的变化。因此，我们不应该再以同样的方式对待所有的 IBD 患者，而是应该重新思考临床分类，并修改治疗方案，为 IBD 进入精准医学时代做好准备。本次 ECCO 科学研讨会旨在提供预后和预测标志物的最新概述，阐明生物标志物开发中的关键问题，提出 IBD 生物标志物开发的最佳实践（包括试验设计），并讨论多组学数据整合的潜力，以帮助推动进一步的进展，使精准医学在 IBD 中成为现实。
