Yu X Y, Li X, Wen Y, Yang Z Y, Zheng Y D, Feng X S, Lyu Z Y, Li N, He J
Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Department of Medical Records, Henan Provincial People's Hospital/Zhengzhou University People's Hospital, Zhengzhou 450003, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2021 Mar 6;55(3):359-364. doi: 10.3760/cma.j.cn112150-20200624-00924.
To investigate the relationship between metabolic syndrome (MS) and the risk of breast cancer in Chinese females. From May 2006 to December 2015, based on the Kailuan Women's Dynamic Cohort,a total of 25 618 female employees and retirees of the Kailuan Group were included and followed. Questionnaire surveys, physical measurements and laboratory tests were used to collect baseline sociodemographic characteristics, height, weight, blood glucose, blood lipids, blood pressure, tumor incidence and outcome information. Cox proportional hazards regression models were used to analyze the relationship between MS and its components (body mass index, blood pressure, blood glucose and blood lipid) and the risk of breast cancer in females. The age of 25 618 women was (47.65±12.02) years old and median follow-up time was 8.78 years; 235 new cases of breast cancer were detected, and the incidence density was 113.19/100 000 person-years. After adjusting for age, education, income, smoking status, drinking status and other factors, people who were overweight or obese had a higher risk of breast cancer, with (95%) about 1.47 (1.12-1.93), than those with normal body mass index. Compared with those without MS abnormal components, women with two MS abnormal components had an increased risk of breast cancer (=1.70, 95%: 1.16-2.50). With the increase of the number of MS abnormal components, the risk of breast cancer increased gradually ( value<0.05). Overweight/obesity and the number of abnormal components of MS can increase the risk of breast cancer in women.
探讨中国女性代谢综合征（MS）与乳腺癌风险之间的关系。2006年5月至2015年12月，基于开滦女性动态队列，共纳入开滦集团25618名女性员工和退休人员并进行随访。采用问卷调查、体格检查和实验室检测收集基线社会人口学特征、身高、体重、血糖、血脂、血压、肿瘤发病及转归信息。使用Cox比例风险回归模型分析MS及其组分（体重指数、血压、血糖和血脂）与女性乳腺癌风险之间的关系。25618名女性年龄为（47.65±12.02）岁，中位随访时间为8.78年；共检测到235例新发乳腺癌病例，发病密度为113.19/100000人年。在调整年龄、教育程度、收入、吸烟状况、饮酒状况等因素后，超重或肥胖者患乳腺癌的风险较高，约为（95%）1.47（1.12 - 1.93），高于体重指数正常者。与无MS异常组分者相比，有两个MS异常组分的女性患乳腺癌的风险增加（=1.70，95%：1.16 - 2.50）。随着MS异常组分数量的增加，乳腺癌风险逐渐升高（值<0.05）。超重/肥胖及MS异常组分数量可增加女性患乳腺癌的风险。
