Chen Ping, Zeng Ping, Gong Yuan, Long Xiang
The First College of Clinical Medical Science, China Three Gorges University; Department of Anesthesiology, Yichang Central People's Hospital, Hubei, China.
J Int Med Res. 2021 Mar;49(3):300060521996143. doi: 10.1177/0300060521996143.
Sufentanil-induced cough (SIC) is a common complication during anesthesia induction. We explored the recommended sufentanil dose that effectively avoids cough during general anesthesia using a clinical trial to analyze the effective dose (ED)50 and ED95 of sufentanil that avoids cough, hemodynamic fluctuations, and adverse reactions.
On the basis of sufentanil dose, 136 patients (ASA class I-II) were randomly allocated into the following groups: I, 0.1 μg/kg; II, 0.3 μg/kg; III, 0.5 μg/kg; or IV, 1.0 μg/kg. The number of coughing incidents, dizziness, panic, and chest tightness within 1 minute after sufentanil injection, and the patient's heart rate (HR) and blood pressure 5 minutes after intubation were recorded and analyzed. Cough was assessed as follows: none, 0 times; mild, 1 to 2 times/minute; moderate, 3 to 4 times/minute; and severe, 5 times/minute or more.
The ED50 and ED95 of cough incidence induced by intravenous sufentanil in patients during general anesthesia induction was 0.332 μg/kg and 1.423 μg/kg, respectively. The cough rate in group I was lower than the other groups. The incidence of dizziness, panic, chest tightness, hypertension, bradycardia, and tachycardia were not significantly different.
The recommended sufentanil dose during general anesthesia induction is 0.1 μg/kg.
舒芬太尼诱发咳嗽（SIC）是麻醉诱导期间的常见并发症。我们通过一项临床试验探索了在全身麻醉期间有效避免咳嗽的舒芬太尼推荐剂量，以分析避免咳嗽、血流动力学波动及不良反应的舒芬太尼有效剂量（ED）50和ED95。
根据舒芬太尼剂量，将136例患者（美国麻醉医师协会分级I-II级）随机分为以下几组：I组，0.1μg/kg；II组，0.3μg/kg；III组，0.5μg/kg；或IV组，1.0μg/kg。记录并分析舒芬太尼注射后1分钟内的咳嗽次数、头晕、恐慌和胸闷情况，以及插管后5分钟时患者的心率（HR）和血压。咳嗽评估如下：无，0次；轻度，每分钟1至2次；中度，每分钟3至4次；重度，每分钟5次或更多。
全身麻醉诱导期间患者静脉注射舒芬太尼诱发咳嗽发生率的ED50和ED95分别为0.332μg/kg和1.423μg/kg。I组的咳嗽发生率低于其他组。头晕、恐慌、胸闷、高血压、心动过缓和心动过速的发生率无显著差异。
全身麻醉诱导期间舒芬太尼的推荐剂量为0.1μg/kg。
