Verma N P, Desai S G, Simon M R, King S D
Neurology Service, Veterans Administration Medical Center, Allen Park, MI 48101.
J Lab Clin Med. 1988 Jun;111(6):692-700.
Neurosarcoidosis is suspected on clinical grounds and then confirmed by radiography, by spinal fluid examination, or by biopsy. To determine whether evoked potential testing may also be of value in diagnosing and following the course of neurosarcoidosis, multimodality evoked potentials were obtained in 12 men with sarcoidosis, including two with neurosarcoidosis. Seven of 12 subjects, one of whom had neurosarcoidosis, manifested abnormal evoked potentials. Visual evoked potentials were abnormal in one patient and somatosensory evoked potentials were abnormal in one patient. Five additional patients, including one with neurosarcoidosis, had abnormal auditory evoked potentials suggestive of auditory nerve or low pons involvement. These data indicate that multimodality evoked potentials, especially auditory potentials, may show central nervous system involvement in patients with sarcoidosis in the absence of clinically apparent disease.
神经结节病基于临床症状被怀疑，然后通过放射检查、脑脊液检查或活检得以确诊。为了确定诱发电位检测在神经结节病的诊断及病程监测中是否也有价值，对12名结节病男性患者进行了多模式诱发电位检测，其中包括两名神经结节病患者。12名受试者中有7名诱发电位异常，其中1名患有神经结节病。1例患者视觉诱发电位异常，1例患者体感诱发电位异常。另外5例患者，包括1例神经结节病患者，听觉诱发电位异常，提示听神经或脑桥下部受累。这些数据表明，多模式诱发电位，尤其是听觉诱发电位，可能在结节病患者无明显临床疾病时显示中枢神经系统受累情况。
