Holczer Adrienn, Németh Viola Luca, Vékony Teodóra, Kocsis Krisztián, Király András, Kincses Zsigmond Tamás, Vécsei László, Klivényi Péter, Must Anita
Department of Neurology, Faculty of Medicine, Albert Szent-Györgyi Health Centre, University of Szeged, Szeged, Hungary.
Department of Neurology, Faculty of Medicine, Albert Szent-Györgyi Health Centre, University of Szeged, Szeged, Hungary; Lyon Neuroscience Research Center (CRNL), INSERM, CNRS, Université Claude Bernard Lyon 1, Lyon, France.
Neuroscience. 2021 May 1;461:130-139. doi: 10.1016/j.neuroscience.2021.03.001. Epub 2021 Mar 14.
Major depressive disorder (MDD) is characterized by severe affective as well as cognitive symptoms. Moreover, cognitive impairment in MDD can persist after the remission of affective symptoms. Theta-burst stimulation (TBS) is a promising tool to manage the affective symptoms of major depressive disorder (MDD); however, its cognition-enhancing effects are sparsely investigated. Here, we aimed to examine whether the administration of bilateral TBS has pro-cognitive effects in MDD. Ten daily sessions of neuronavigated active or sham TBS were delivered bilaterally over the dorsolateral prefrontal cortex to patients with MDD. The n-back task and the attention network task were administered to assess working memory and attention, respectively. Affective symptoms were measured using the 21-item Hamilton Depression Rating Scale. We observed moderate evidence that the depressive symptoms of patients receiving active TBS improved compared to participants in the sham stimulation. No effects of TBS on attention and working memory were detected, supported by a moderate-to-strong level of evidence. The effects of TBS on psychomotor processing speed should be further investigated. Bilateral TBS has a substantial antidepressive effect with no immediate adverse effects on executive functions.
重度抑郁症（MDD）的特征是严重的情感和认知症状。此外，MDD中的认知障碍在情感症状缓解后仍可能持续。theta爆发刺激（TBS）是一种有前景的治疗重度抑郁症（MDD）情感症状的工具；然而，其对认知增强的作用研究较少。在此，我们旨在研究双侧TBS给药对MDD患者是否具有促认知作用。对MDD患者双侧背外侧前额叶皮层进行了为期十天的神经导航主动或假TBS治疗。分别使用n-back任务和注意力网络任务来评估工作记忆和注意力。使用21项汉密尔顿抑郁量表测量情感症状。我们观察到适度的证据表明，与接受假刺激的参与者相比，接受主动TBS治疗的患者的抑郁症状有所改善。有中等到强烈程度的证据支持，未检测到TBS对注意力和工作记忆有影响。TBS对心理运动处理速度的影响应进一步研究。双侧TBS具有显著的抗抑郁作用，且对执行功能无即时不良影响。
