Ferrinho Cátia, Silva Eugénia, Oliveira Manuela, Sequeira Duarte João
Endocrinology, Centro Hospitalar de Lisboa Ocidental EPE Hospital de Egas Moniz, Lisboa, Portugal
Endocrinology, Centro Hospitalar de Lisboa Ocidental EPE Hospital de Egas Moniz, Lisboa, Portugal.
BMJ Case Rep. 2021 Mar 17;14(3):e240937. doi: 10.1136/bcr-2020-240937.
A 71-year-old woman was referred to the endocrinology clinic to investigate postmenopausal hirsutism with 10 years of evolution. She had history of regular menses and menopause with 50 years old. Physical examination showed a male pattern facies, deepening of the voice, androgenic alopecia and hirsutism with a score of 23 according to the modified Ferriman-Gallwey scale. Testosterone and androstenedione were increased. Transvaginal ultrasound, abdominal and pelvic CT showed uterine fibroids with no pathological findings in the adrenals or ovaries. Since she had postmenopausal vaginal bleeding, uterine fibroids and suspicion of an ovarian source for her hyperandrogenism, total hysterectomy and bilateral oophorectomy were performed. Histopathological diagnosis was a Leydig cell tumour located in left ovary and endometrial carcinoma. Improvement of hirsutism was started to notice 1 month after the surgery and she was referred to the oncology clinic for adjuvant treatment.
一名71岁女性因绝经后多毛症就诊于内分泌科，病程已有10年。她月经规律，50岁绝经。体格检查显示呈男性化面容、声音低沉、雄激素性脱发以及多毛症，根据改良的费里曼-盖尔韦量表评分为23分。睾酮和雄烯二酮水平升高。经阴道超声、腹部及盆腔CT检查显示有子宫肌瘤，肾上腺及卵巢未发现病理改变。由于她出现绝经后阴道出血、子宫肌瘤且怀疑其高雄激素血症源于卵巢，遂行全子宫切除术及双侧卵巢切除术。组织病理学诊断为左侧卵巢的莱迪希细胞瘤及子宫内膜癌。术后1个月开始注意到多毛症有所改善，她随后被转至肿瘤科进行辅助治疗。
