拯救脓毒症运动：成年患者液体复苏和血管活性药物治疗研究重点
The Surviving Sepsis Campaign: Fluid Resuscitation and Vasopressor Therapy Research Priorities in Adult Patients.
作者信息
Lat Ishaq, Coopersmith Craig M, De Backer Daniel
机构信息
Department of Pharmacy, Shirley Ryan AbilityLab, Chicago, IL.
Department of Surgery and Emory Critical Care Center, Emory University, Atlanta, GA.
出版信息
Crit Care Med. 2021 Apr 1;49(4):623-635. doi: 10.1097/CCM.0000000000004864.
Abstract
OBJECTIVE
Expand upon the priorities of fluid resuscitation and vasopressor therapy research priorities identified by a group of experts assigned by the Society of Critical Care Medicine and the European Society of Intensive Care Medicine.
DATA SOURCES
Original article, literature search.
STUDY SELECTION
Several members of the original task force with expertise specific to the area of fluid resuscitation and vasopressor therapy.
DATA EXTRACTION
None.
DATA SYNTHESIS
None.
CONCLUSION
In the second of a series of manuscripts subsequent to the original article, members with expertise in the subjects expound upon the three identified priorities related to fluid resuscitation and vasopressor therapies. This analysis summarizes what is known and what were identified as ongoing and future research.
摘要
目的
详细阐述由危重病医学会和欧洲重症监护医学会指定的一组专家确定的液体复苏和血管加压药治疗研究重点的优先事项。
数据来源
原始文章、文献检索。
研究选择
原始特别工作组中几位在液体复苏和血管加压药治疗领域具有特定专业知识的成员。
数据提取
无。
数据综合
无。
结论
在原始文章之后的一系列手稿中的第二篇，该主题的专家成员详细阐述了与液体复苏和血管加压药治疗相关的三个确定的优先事项。本分析总结了已知内容以及确定为正在进行和未来的研究。
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本文引用的文献
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Crit Care Explor. 2019 May 23;1(5):e0015. doi: 10.1097/CCE.0000000000000015. eCollection 2019 May.
2
Effect of Reduced Exposure to Vasopressors on 90-Day Mortality in Older Critically Ill Patients With Vasodilatory Hypotension: A Randomized Clinical Trial.降低血管升压药暴露对老年血管舒张性低血压危重症患者90天死亡率的影响：一项随机临床试验
JAMA. 2020 Mar 10;323(10):938-949. doi: 10.1001/jama.2020.0930.
3
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7
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