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Resuscitation Guided by Volume Responsiveness Does Not Reduce Mortality in Sepsis: A Meta-Analysis.容量反应性指导下的复苏不能降低脓毒症死亡率:一项荟萃分析。
Crit Care Explor. 2019 May 23;1(5):e0015. doi: 10.1097/CCE.0000000000000015. eCollection 2019 May.
2
Effect of Reduced Exposure to Vasopressors on 90-Day Mortality in Older Critically Ill Patients With Vasodilatory Hypotension: A Randomized Clinical Trial.降低血管升压药暴露对老年血管舒张性低血压危重症患者90天死亡率的影响:一项随机临床试验
JAMA. 2020 Mar 10;323(10):938-949. doi: 10.1001/jama.2020.0930.
3
Lower vs Higher Fluid Volumes During Initial Management of Sepsis: A Systematic Review With Meta-Analysis and Trial Sequential Analysis.低容量与高容量液体复苏治疗脓毒症的初始阶段:系统评价、Meta 分析与序贯试验分析。
Chest. 2020 Jun;157(6):1478-1496. doi: 10.1016/j.chest.2019.11.050. Epub 2020 Jan 23.
4
Association Between Volume of Fluid Resuscitation and Intubation in High-Risk Patients With Sepsis, Heart Failure, End-Stage Renal Disease, and Cirrhosis.容量复苏与高危患者脓毒症、心力衰竭、终末期肾病和肝硬化患者插管的关系。
Chest. 2020 Feb;157(2):286-292. doi: 10.1016/j.chest.2019.09.029. Epub 2019 Oct 14.
5
154 compared to 54 mmol per liter of sodium in intravenous maintenance fluid therapy for adult patients undergoing major thoracic surgery (TOPMAST): a single-center randomized controlled double-blind trial.与成人胸部大手术(TOPMAST)患者静脉维持液治疗中 54mmol/L 的钠相比,154mmol/L 的钠:一项单中心随机对照双盲试验。
Intensive Care Med. 2019 Oct;45(10):1422-1432. doi: 10.1007/s00134-019-05772-1. Epub 2019 Oct 1.
6
Effects of a Resuscitation Strategy Targeting Peripheral Perfusion Status versus Serum Lactate Levels among Patients with Septic Shock. A Bayesian Reanalysis of the ANDROMEDA-SHOCK Trial.以外周灌注状态为目标的复苏策略与脓毒性休克患者血清乳酸水平的影响。ANDROMEDA-SHOCK 试验的贝叶斯再分析。
Am J Respir Crit Care Med. 2020 Feb 15;201(4):423-429. doi: 10.1164/rccm.201905-0968OC.
7
Balanced Crystalloids versus Saline in Sepsis. A Secondary Analysis of the SMART Clinical Trial.脓毒症患者中平衡晶体液与生理盐水的比较: SMART 临床试验的二次分析。
Am J Respir Crit Care Med. 2019 Dec 15;200(12):1487-1495. doi: 10.1164/rccm.201903-0557OC.
8
Balanced Crystalloids Versus Saline in Critically Ill Adults: A Systematic Review and Meta-analysis.平衡晶体液与生理盐水在危重症成人中的比较:系统评价和荟萃分析。
Ann Pharmacother. 2020 Jan;54(1):5-13. doi: 10.1177/1060028019866420. Epub 2019 Jul 31.
9
Lactated Ringer's Versus 4% Albumin on Lactated Ringer's in Early Sepsis Therapy in Cancer Patients: A Pilot Single-Center Randomized Trial.乳酸林格氏液与白蛋白联合乳酸林格氏液在癌症患者早期脓毒症治疗中的比较:一项单中心随机试验的初步研究。
Crit Care Med. 2019 Oct;47(10):e798-e805. doi: 10.1097/CCM.0000000000003900.
10
Buffered solutions versus 0.9% saline for resuscitation in critically ill adults and children.用于重症成人和儿童复苏的缓冲溶液与0.9%生理盐水的比较。
Cochrane Database Syst Rev. 2019 Jul 19;7(7):CD012247. doi: 10.1002/14651858.CD012247.pub2.

拯救脓毒症运动:成年患者液体复苏和血管活性药物治疗研究重点

The Surviving Sepsis Campaign: Fluid Resuscitation and Vasopressor Therapy Research Priorities in Adult Patients.

作者信息

Lat Ishaq, Coopersmith Craig M, De Backer Daniel

机构信息

Department of Pharmacy, Shirley Ryan AbilityLab, Chicago, IL.

Department of Surgery and Emory Critical Care Center, Emory University, Atlanta, GA.

出版信息

Crit Care Med. 2021 Apr 1;49(4):623-635. doi: 10.1097/CCM.0000000000004864.

DOI:10.1097/CCM.0000000000004864
PMID:33731607
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7963440/
Abstract

OBJECTIVE

Expand upon the priorities of fluid resuscitation and vasopressor therapy research priorities identified by a group of experts assigned by the Society of Critical Care Medicine and the European Society of Intensive Care Medicine.

DATA SOURCES

Original article, literature search.

STUDY SELECTION

Several members of the original task force with expertise specific to the area of fluid resuscitation and vasopressor therapy.

DATA EXTRACTION

None.

DATA SYNTHESIS

None.

CONCLUSION

In the second of a series of manuscripts subsequent to the original article, members with expertise in the subjects expound upon the three identified priorities related to fluid resuscitation and vasopressor therapies. This analysis summarizes what is known and what were identified as ongoing and future research.

摘要

目的

详细阐述由危重病医学会和欧洲重症监护医学会指定的一组专家确定的液体复苏和血管加压药治疗研究重点的优先事项。

数据来源

原始文章、文献检索。

研究选择

原始特别工作组中几位在液体复苏和血管加压药治疗领域具有特定专业知识的成员。

数据提取

无。

数据综合

无。

结论

在原始文章之后的一系列手稿中的第二篇,该主题的专家成员详细阐述了与液体复苏和血管加压药治疗相关的三个确定的优先事项。本分析总结了已知内容以及确定为正在进行和未来的研究。