Michalczyk Kaja, Cymbaluk-Płoska Aneta
Department of Gynecological Surgery and Oncology of Adults and Adolescents, Pomeranian Medical University, Szczecin, Poland.
Cancer Manag Res. 2021 Mar 11;13:2329-2339. doi: 10.2147/CMAR.S290592. eCollection 2021.
Ovarian cancer is one of the most common gynecological cancers diagnosed in pregnancy. Its management is often very problematic due to the proximity of the adnexa to the developing fetus and chemotherapy-related toxicity risk. Tumor markers and imagining studies play important roles in diagnosis, help differentiate benign masses from malignancy and allow to plan the treatment. Due to the physiological changes that occur in pregnancy, levels of tumor markers can be altered and reduce their diagnostic value. We review current recommendations for the management and treatment of ovarian cancer in pregnant patients considering gestational age at diagnosis, tumor histology, stage of the disease, risk of obstetrical complications, and patient's preferences.
卵巢癌是孕期诊断出的最常见妇科癌症之一。由于附件与发育中的胎儿距离较近以及化疗相关的毒性风险，其治疗往往非常棘手。肿瘤标志物和影像学检查在诊断中发挥着重要作用，有助于区分良性肿块与恶性肿瘤，并为治疗方案的制定提供依据。由于孕期会发生生理变化，肿瘤标志物水平可能会改变，从而降低其诊断价值。我们根据诊断时的孕周、肿瘤组织学类型、疾病分期、产科并发症风险以及患者偏好，综述了目前关于妊娠合并卵巢癌患者管理和治疗的建议。
