• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

C-藻蓝蛋白——一种来自……的新型蛋白质——毒性、抗氧化和免疫调节研究 。 （注：原文中“from -”这里表述不完整，可能存在信息缺失）

C-Phycocyanin-a novel protein from - toxicity, antioxidant and immunomodulatory studies.

作者信息

Grover Priyanka, Bhatnagar Aseem, Kumari Neeraj, Narayan Bhatt Ananth, Kumar Nishad Dhruv, Purkayastha Jubilee

机构信息

Institute of Nuclear Medicine and Allied Sciences (INMAS), Defence Research and Development Organisation (DRDO), Brig. S.K. Majumdar Marg, Delhi 110054, India.

出版信息

Saudi J Biol Sci. 2021 Mar;28(3):1853-1859. doi: 10.1016/j.sjbs.2020.12.037. Epub 2020 Dec 30.

DOI:10.1016/j.sjbs.2020.12.037
PMID:33732072
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7938138/
Abstract

A pigment-protein highly dominant in Spirulina is known as C-Phycocyanin. Earlier, studies has shown that C-phycocyanin is having many biological activities like antioxidant and anti-inflammatory activities, antiplatelet, hepatoprotective, and cholesterol-lowering properties. Interestingly, there are scanty experimental findings on the immunomodulatory and antioxidant effects of C-phycocyanin. This work is aimed at evaluation of the effects of C-phycocyanin on immunomodulation and antioxidant potential in Balb/c mice. Our results of toxicity, immunomodulatory and antioxidant effects of C-Phycocyanin suggests that C-phycocyanin is very safe for consumption and having substantial antioxidant potential and also possess immunomodulatory activities in Balb/c mice in a dosage dependent manner. C-phycocyanin doesn't cause acute and subacute toxicity in the animal model (male, Balb/c mice) studied. We have reported that C-phycocyanin exhibited immunomodulation performance in this animal model.

摘要

一种在螺旋藻中高度占主导地位的色素蛋白被称为C-藻蓝蛋白。此前，研究表明C-藻蓝蛋白具有许多生物活性，如抗氧化和抗炎活性、抗血小板、肝脏保护和降低胆固醇的特性。有趣的是，关于C-藻蓝蛋白的免疫调节和抗氧化作用的实验结果很少。这项工作旨在评估C-藻蓝蛋白对Balb/c小鼠免疫调节和抗氧化潜力的影响。我们关于C-藻蓝蛋白毒性、免疫调节和抗氧化作用的结果表明，C-藻蓝蛋白食用起来非常安全，具有强大的抗氧化潜力，并且在Balb/c小鼠中也具有剂量依赖性的免疫调节活性。在所研究的动物模型（雄性Balb/c小鼠）中，C-藻蓝蛋白不会引起急性和亚急性毒性。我们已经报道C-藻蓝蛋白在该动物模型中表现出免疫调节性能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e58/7938138/7da24c7366b9/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e58/7938138/a6cef428944b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e58/7938138/65e78f91d630/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e58/7938138/7da24c7366b9/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e58/7938138/a6cef428944b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e58/7938138/65e78f91d630/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e58/7938138/7da24c7366b9/gr3.jpg

相似文献

1
C-Phycocyanin-a novel protein from - toxicity, antioxidant and immunomodulatory studies.C-藻蓝蛋白——一种来自……的新型蛋白质——毒性、抗氧化和免疫调节研究 。 （注：原文中“from -”这里表述不完整，可能存在信息缺失）
Saudi J Biol Sci. 2021 Mar;28(3):1853-1859. doi: 10.1016/j.sjbs.2020.12.037. Epub 2020 Dec 30.
2
[ phycocyanins: a perspective for use in foods for special dietary uses (brief review)].[藻蓝蛋白：用于特殊膳食用食品的前景（简要综述）]
Vopr Pitan. 2022;91(6):30-36. doi: 10.33029/0042-8833-2022-91-6-30-36. Epub 2022 Oct 10.
3
Photodynamic effect and mechanism study of selenium-enriched phycocyanin from Spirulina platensis against liver tumours.富硒螺旋藻藻蓝蛋白对肝癌的光动力效应及机制研究。
J Photochem Photobiol B. 2018 Mar;180:89-97. doi: 10.1016/j.jphotobiol.2017.12.020. Epub 2017 Dec 20.
4
Two Classes of Pigments, Carotenoids and C-Phycocyanin, in Spirulina Powder and Their Antioxidant Activities.螺旋藻粉中的两类色素，类胡萝卜素和 C-藻蓝蛋白及其抗氧化活性。
Molecules. 2018 Aug 17;23(8):2065. doi: 10.3390/molecules23082065.
5
The antioxidant, immunomodulatory, and anti-inflammatory activities of Spirulina: an overview.螺旋藻的抗氧化、免疫调节和抗炎活性：概述。
Arch Toxicol. 2016 Aug;90(8):1817-40. doi: 10.1007/s00204-016-1744-5. Epub 2016 Jun 3.
6
Neuroprotection by Spirulina platensis protean extract and phycocyanin against iron-induced toxicity in SH-SY5Y neuroblastoma cells.钝顶螺旋藻多种提取物和藻蓝蛋白对铁诱导的SH-SY5Y神经母细胞瘤细胞毒性的神经保护作用。
Toxicol In Vitro. 2008 Sep;22(6):1496-502. doi: 10.1016/j.tiv.2008.05.004. Epub 2008 May 20.
7
Production of the α and β Subunits of Spirulina Allophycocyanin and C-Phycocyanin in Escherichia coli : A Comparative Study of Their Antioxidant Activities.钝顶螺旋藻别藻蓝蛋白和藻蓝蛋白α和β亚基在大肠杆菌中的表达：其抗氧化活性的比较研究
J Biomol Screen. 2014 Jul;19(6):959-65. doi: 10.1177/1087057113520565. Epub 2014 Jan 24.
8
Phycobiliprotein C-phycocyanin from Spirulina platensis is powerfully responsible for reducing oxidative stress and NADPH oxidase expression induced by an atherogenic diet in hamsters.来自钝顶螺旋藻的藻胆蛋白C-藻蓝蛋白对减轻仓鼠动脉粥样硬化饮食诱导的氧化应激和NADPH氧化酶表达具有强大作用。
J Agric Food Chem. 2007 Sep 19;55(19):7962-7. doi: 10.1021/jf070529g. Epub 2007 Aug 16.
9
In vitro antioxidant and antiproliferative activities of selenium-containing phycocyanin from selenium-enriched Spirulina platensis.富硒钝顶螺旋藻中含硒藻蓝蛋白的体外抗氧化和抗增殖活性
J Agric Food Chem. 2008 Jun 25;56(12):4352-8. doi: 10.1021/jf073399k. Epub 2008 Jun 4.
10
Supplementation of Spirulina (Arthrospira platensis) Improves Lifespan and Locomotor Activity in Paraquat-Sensitive DJ-1β Flies, a Parkinson's Disease Model in Drosophila melanogaster.补充螺旋藻（钝顶节旋藻）可延长对百草枯敏感的DJ-1β果蝇（果蝇帕金森病模型）的寿命并改善其运动活性。
J Diet Suppl. 2017 Sep 3;14(5):573-588. doi: 10.1080/19390211.2016.1275917. Epub 2017 Feb 6.

引用本文的文献

1
Comprehensive investigation into the preventive and therapeutic efficacy and underlying mechanisms of phycocyanin in diabetic retinopathy in rats.藻蓝蛋白对大鼠糖尿病视网膜病变预防和治疗效果及潜在机制的综合研究
Am J Transl Res. 2025 Jul 15;17(7):5344-5354. doi: 10.62347/YZLY5938. eCollection 2025.
2
Investigation of the effect of C-phycocyanin on sonic hedgehog pathway-related Gli1 and Bcl-2 gene expression in MKN45 gastric cancer cells.藻蓝蛋白对MKN45胃癌细胞中与音猬因子信号通路相关的Gli1和Bcl-2基因表达的影响研究
Med Oncol. 2025 Jul 23;42(8):370. doi: 10.1007/s12032-025-02748-8.
3
The combined effects of extended feeding with a high level of Arthrospira platensis and a commercial enzyme mix or porcine pancreatin on broilers' blood cells, plasma metabolites and liver lipid profile.

本文引用的文献

1
In vitro characterization and in vivo toxicity, antioxidant and immunomodulatory effect of fermented foods; Xeniji™.发酵食品Xeniji™的体外特性及体内毒性、抗氧化和免疫调节作用
BMC Complement Altern Med. 2017 Jun 30;17(1):344. doi: 10.1186/s12906-017-1845-6.
2
Antioxidant, Immunomodulating, and Microbial-Modulating Activities of the Sustainable and Ecofriendly .可持续且环保的[物质]的抗氧化、免疫调节及微生物调节活性
Oxid Med Cell Longev. 2017;2017:3247528. doi: 10.1155/2017/3247528. Epub 2017 Jan 15.
3
Blood Levels of Oxidant/Antioxidant Parameters in Rats Infected with .
高水平钝顶螺旋藻与商业酶混合物或猪胰酶联合长期饲喂对肉鸡血细胞、血浆代谢物及肝脏脂质谱的影响。
BMC Vet Res. 2025 Jul 17;21(1):472. doi: 10.1186/s12917-025-04532-2.
4
Phycobilins Versatile Pigments with Wide-Ranging Applications: Exploring Their Uses, Biological Activities, Extraction Methods and Future Perspectives.藻胆蛋白：具有广泛应用的多功能色素——探索其用途、生物活性、提取方法及未来展望
Mar Drugs. 2025 May 4;23(5):201. doi: 10.3390/md23050201.
5
Co-Encapsulation of Phycocyanin and Albumin-Bound Curcumin in Biopolymeric Hydrogels.藻蓝蛋白与白蛋白结合姜黄素在生物聚合物水凝胶中的共包封
Int J Mol Sci. 2025 Apr 17;26(8):3805. doi: 10.3390/ijms26083805.
6
Evaluation of the protective effects of Spirulina platensis against cyclophosphamide-induced genotoxicity.钝顶螺旋藻对环磷酰胺诱导的遗传毒性的保护作用评估。
Lab Anim Res. 2025 Apr 22;41(1):10. doi: 10.1186/s42826-025-00242-w.
7
Unraveling the unique bioactivities of highly purified C-phycocyanin and allophycocyanin.解析高纯度C-藻蓝蛋白和别藻蓝蛋白的独特生物活性。
J Biol Eng. 2025 Apr 16;19(1):34. doi: 10.1186/s13036-025-00496-x.
8
Phycochemistry and pharmacological significance of filamentous cyanobacterium Spirulina sp.丝状蓝藻螺旋藻的藻化学及其药理学意义
Bioresour Bioprocess. 2025 Apr 3;12(1):27. doi: 10.1186/s40643-025-00861-0.
9
Application of microbial pigments in the pharmaceutical industry: current status and opportunities.微生物色素在制药行业中的应用：现状与机遇
Arch Microbiol. 2025 Mar 31;207(5):104. doi: 10.1007/s00203-025-04261-y.
10
The antiparasitic effect of C-Phycocyanin nanoparticles on cryptosporidiosis in immunosuppressed mice.C-藻蓝蛋白纳米颗粒对免疫抑制小鼠隐孢子虫病的抗寄生虫作用。
J Parasit Dis. 2025 Mar;49(1):173-185. doi: 10.1007/s12639-024-01739-2. Epub 2024 Oct 3.
感染……的大鼠体内氧化/抗氧化参数的血液水平
Oxid Med Cell Longev. 2016;2016:8045969. doi: 10.1155/2016/8045969. Epub 2016 Sep 26.
4
Co-production of carbonic anhydrase and phycobiliproteins by Spirulina sp. and Synechococcus nidulans.钝顶螺旋藻和钝顶节杆菌共生产碳酸酐酶和藻胆蛋白。
Bioresour Technol. 2016 Nov;219:219-227. doi: 10.1016/j.biortech.2016.07.133. Epub 2016 Jul 30.
5
Roles of glutathione in antioxidant defense, inflammation, and neuron differentiation in the thalamus of HIV-1 transgenic rats.谷胱甘肽在HIV-1转基因大鼠丘脑抗氧化防御、炎症及神经元分化中的作用。
J Neuroimmune Pharmacol. 2014 Jun;9(3):413-23. doi: 10.1007/s11481-014-9538-0. Epub 2014 Mar 8.
6
Interactions between prebiotics, probiotics, polyunsaturated fatty acids and polyphenols: diet or supplementation for metabolic syndrome prevention?益生元、益生菌、多不饱和脂肪酸和多酚之间的相互作用：通过饮食还是补充剂预防代谢综合征？
Int J Food Sci Nutr. 2014 May;65(3):259-67. doi: 10.3109/09637486.2014.880670. Epub 2014 Jan 28.
7
Cytokine networking of innate immunity cells: a potential target of therapy.固有免疫细胞的细胞因子网络：治疗的潜在靶点。
Clin Sci (Lond). 2014 May;126(9):593-612. doi: 10.1042/CS20130497.
8
Spirulina platensis and phycocyanobilin activate atheroprotective heme oxygenase-1: a possible implication for atherogenesis.钝顶螺旋藻和藻蓝蛋白激活抗动脉粥样硬化血红素加氧酶-1：对动脉粥样生成的一种可能影响。
Food Funct. 2013 Nov;4(11):1586-94. doi: 10.1039/c3fo60230c.
9
Phycocyanin prevents hypertension and low serum adiponectin level in a rat model of metabolic syndrome.藻蓝蛋白可预防代谢综合征大鼠模型的高血压和低血清脂联素水平。
Nutr Res. 2013 May;33(5):397-405. doi: 10.1016/j.nutres.2013.03.006. Epub 2013 Apr 18.
10
Extracts from Citrus unshiu promote immune-mediated inhibition of tumor growth in a murine renal cell carcinoma model.从柚子中提取的物质可促进免疫介导的肿瘤生长抑制作用，在一种小鼠肾细胞癌模型中。
J Ethnopharmacol. 2011 Feb 16;133(3):973-9. doi: 10.1016/j.jep.2010.07.018. Epub 2010 Jul 14.