Department of Immunology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Front Immunol. 2021 Feb 24;12:639844. doi: 10.3389/fimmu.2021.639844. eCollection 2021.
The Epstein-Barr virus (EBV) is endemic in humans and can efficiently transform infected B cells under some circumstances. If an EBV carrier experiences immune suppression, EBV B cells can turn into lymphoblasts and exhibit growth expansion that may cause lymphoproliferative diseases which often develop into lymphoma. Our immune system conducts surveillance for EBV B cells in order to block spontaneous tumor formation. Here, we summarize the EBV products involved in tumorigenesis, EBV-associated lymphomas, and pathologically relevant mouse models. Preclinical mouse models for a range of EBV-associated diseases not only clear the path to new therapeutic approaches but also aid in our understanding of the nature of lymphomagenesis and immune surveillance.
EB 病毒（EBV）在人类中普遍存在，在某些情况下可以有效地将受感染的 B 细胞转化。如果 EBV 携带者经历免疫抑制，EBV B 细胞可能会转化为淋巴母细胞，并表现出生长扩张，从而导致淋巴组织增生性疾病，通常发展为淋巴瘤。我们的免疫系统会对 EBV B 细胞进行监测，以阻止自发性肿瘤形成。在这里，我们总结了参与肿瘤发生、EBV 相关淋巴瘤以及与病理相关的小鼠模型的 EBV 产物。针对一系列 EBV 相关疾病的临床前小鼠模型不仅为新的治疗方法开辟了道路，还有助于我们了解淋巴瘤发生和免疫监测的本质。
