Cesarman Ethel
Department of Pathology, Weill Medical College of Cornell University, New York, NY 10021, USA.
Front Biosci. 2002 Feb 1;7:e58-65. doi: 10.2741/A907.
Epstein Barr virus (EBV) is a gamma herpesvirus that is associated with several specific lymphoid malignancies, some of which occur more frequently in immunocompromised individuals. EBV infection is almost ubiquitous in healthy adults, so establishing a causal role in lymphomagenesis has been difficult. Support for EBV being an oncogenic virus is derived from its ability to infect and transform normal human B-cells in vitro, resulting in their "immortalization" and leading to continuously growing lymphoblastoid cell lines (LCLs). In addition, viral proteins required for this EBV-mediated transformation have been identified. The presence of EBV in the neoplastic cells of specific lymphoid malignancies is quite consistent, further indicating an etiopathogenic role in their development. Nevertheless, it is clear that while important in the process of lymphomagenesis, infection by EBV is not sufficient. Important co-factors exist for the development of EBV-associated lymphomas, one of which is the lack of normal immune surveillance.
爱泼斯坦-巴尔病毒（EBV）是一种γ疱疹病毒，与多种特定的淋巴系统恶性肿瘤相关，其中一些在免疫功能低下的个体中更常见。EBV感染在健康成年人中几乎无处不在，因此确定其在淋巴瘤发生中的因果作用一直很困难。支持EBV是一种致癌病毒的依据来自于它在体外感染和转化正常人B细胞的能力，导致这些细胞“永生化”并形成持续生长的淋巴母细胞系（LCLs）。此外，已经确定了这种EBV介导的转化所需的病毒蛋白。EBV在特定淋巴系统恶性肿瘤的肿瘤细胞中的存在相当一致，进一步表明其在肿瘤发生过程中的病因学作用。然而，很明显，虽然EBV在淋巴瘤发生过程中很重要，但感染EBV并不足以引发疾病。EBV相关淋巴瘤的发生存在重要的协同因素，其中之一是缺乏正常的免疫监视。
